biostudies-literatureHerring NNIH SPARCBritish Heart FoundationNIDDK NIH HHSNHLBI NIH HHSNational Institutes of HealthHealth Research Council, Marsden Fund, the Royal Society of New Zealand and the Sidney Taylor TrustNIH HHS1729-1779https://www.ebi.ac.uk/biostudies/studies/S-EPMC11955874biostudies-literatureUnknown603(7)In our original white paper published in the The Journal of Physiology in 2016, we set out our knowledge of the structural and functional organization of cardiac autonomic control, how it remodels during disease, and approaches to exploit such knowledge for autonomic regulation therapy. The aim of this update is to build on this original blueprint, highlighting the significant progress which has been made in the field since and major challenges and opportunities that exist with regard to translation. Imbalances in autonomic responses, while beneficial in the short term, ultimately contribute to the evolution of cardiac pathology. As our understanding emerges of where and how to target in terms of actuators (including the heart and intracardiac nervous system (ICNS), stellate ganglia, dorsaThe Journal of physiologyNeurocardiology: translational advancements and potential.PMC11955874R01 HL116476R01HL150136FS/SCRF/20/32005U54AT012307R21 DK128663R01HL162921RG/19/5/34 463P01HL1643111OT2OD023848FS/SCRF/20/32 005Osborn JArdell JLRipplinger CMSmith CVrabec TLHerring NAjijola OAForeman RDPaterson DJZucker IHPaton JFRGourine AVGreen ALWang HJfalseNeurocardiology: translational advancements and potential.In our original white paper published in the The Journal of Physiology in 2016, we set out our knowledge of the structural and functional organization of cardiac autonomic control, how it remodels during disease, and approaches to exploit such knowledge for autonomic regulation therapy. The aim of this update is to build on this original blueprint, highlighting the significant progress which has been made in the field since and major challenges and opportunities that exist with regard to translation. Imbalances in autonomic responses, while beneficial in the short term, ultimately contribute to the evolution of cardiac pathology. As our understanding emerges of where and how to target in terms of actuators (including the heart and intracardiac nervous system (ICNS), stellate ganglia, dorsa2025-01-01T00:00:00Z2025 Mar2026-06-03T05:56:13.292Z2026-04-25T03:16:37.951ZS-EPMC119558743934017310.1113/JP284740