biostudies-literatureGomes FLTKI Green Chemistry and CircularityDutch Research Council (NWO)Health~Holland18179-18193https://www.ebi.ac.uk/biostudies/studies/S-EPMC11955951biostudies-literatureUnknown17(12)Particles are essential building blocks in nanomedicine and cell engineering. Their administration often involves blood contact, which demands a hemocompatible material profile. Coating particles with isolated cell membranes is a common strategy to improve hemocompatibility, but this solution is nonscalable and potentially immunogenic. Cell membrane-like lipid coatings are a promising alternative, as lipids can be synthesized on a large scale and used to create safe cell membrane-like supported bilayers. However, a method to controllably and scalably lipid-coat a wide range of particles has remained elusive. Here, an on-particle solvent-assisted lipid coating (OPSALC) method is introduced as an innovative technique to endow various types of particles with cell membrane-like coatings. CoatiACS applied materials & interfacesOPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility.PMC11955951CHEMIE.PGT.2023.017OCENW.XS23.4.046LSHM19074van Weerd JLeijten JGomes FLEdelbroek RJonkheijm PWasserberg DfalseOPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility.Particles are essential building blocks in nanomedicine and cell engineering. Their administration often involves blood contact, which demands a hemocompatible material profile. Coating particles with isolated cell membranes is a common strategy to improve hemocompatibility, but this solution is nonscalable and potentially immunogenic. Cell membrane-like lipid coatings are a promising alternative, as lipids can be synthesized on a large scale and used to create safe cell membrane-like supported bilayers. However, a method to controllably and scalably lipid-coat a wide range of particles has remained elusive. Here, an on-particle solvent-assisted lipid coating (OPSALC) method is introduced as an innovative technique to endow various types of particles with cell membrane-like coatings. Coati2025-01-01T00:00:00Z2025 Mar2025-07-02T03:04:56.442Z2025-07-02T03:04:56.442ZS-EPMC119559514007978610.1021/acsami.5c02103