{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(1)"],"submitter":["Shao X"],"pubmed_abstract":["<h4>Background</h4>Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation. This study aims to explore the correlation between IBI and depression in the general population.<h4>Methods</h4>This cross-sectional study was designed to analyze the data from National Health and Nutrition Examination Survey (NHANES) during the period from 1999 to 2018. IBI was formulated as C-reactive protein×neutrophils/lymphocytes. The correlation between the prevalence of depression and IBI was explored through multivariate logistic regression analyses, as well as subgroup, interaction, restricted cubic spline (RCS) and sensitivity analyses.<h4>Results</h4>A total o"],"journal":["BMC psychiatry"],"pagination":["306"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11956433"],"repository":["biostudies-literature"],"pubmed_title":["Inflammatory burden index is correlated with increased depression: a population-based study."],"pmcid":["PMC11956433"],"pubmed_authors":["Shao X","Zhu L","Xie Z"],"additional_accession":[]},"is_claimable":false,"name":"Inflammatory burden index is correlated with increased depression: a population-based study.","description":"<h4>Background</h4>Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation. This study aims to explore the correlation between IBI and depression in the general population.<h4>Methods</h4>This cross-sectional study was designed to analyze the data from National Health and Nutrition Examination Survey (NHANES) during the period from 1999 to 2018. IBI was formulated as C-reactive protein×neutrophils/lymphocytes. The correlation between the prevalence of depression and IBI was explored through multivariate logistic regression analyses, as well as subgroup, interaction, restricted cubic spline (RCS) and sensitivity analyses.<h4>Results</h4>A total o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-11T03:03:42.48Z","creation":"2025-07-11T03:03:42.48Z"},"accession":"S-EPMC11956433","cross_references":{"pubmed":["40165155"],"doi":["10.1186/s12888-025-06730-6"]}}