{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(3)"],"submitter":["Dong Y"],"pubmed_abstract":["<h4>Background</h4>Acetaminophen (APAP) can be used for pain relief and fever alleviation, the overdose of which, however, may lead to the accumulation of N-acetyl-p-benzoquinone imine (NAPQI), inducing oxidative stress and liver damage. The natural compound SMND-309 has been shown to have hepatoprotective effects and potential antioxidant activity. However, its ability to alleviate acetaminophen-induced acute liver injury (AILI) has not been elucidated.<h4>Objective</h4>To explore the protective effect of the natural compound SMND-309 against AILI and the potential mechanism.<h4>Methods</h4>The AILI model was established using a mouse model and HepG2 cells for pathological evaluation and biochemical assays of mouse liver tissues to assess the level of liver injury. The effects of SMND-309"],"journal":["PloS one"],"pagination":["e0310879"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11957308"],"repository":["biostudies-literature"],"pubmed_title":["SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress."],"pmcid":["PMC11957308"],"pubmed_authors":["Dong Y","Li Q","Yan R","Shi Z","Wang J","Wang L","Liu W","Li N","Jiang Y","Qiu Y","Ding W","Jia R","Xu S"],"additional_accession":[]},"is_claimable":false,"name":"SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress.","description":"<h4>Background</h4>Acetaminophen (APAP) can be used for pain relief and fever alleviation, the overdose of which, however, may lead to the accumulation of N-acetyl-p-benzoquinone imine (NAPQI), inducing oxidative stress and liver damage. The natural compound SMND-309 has been shown to have hepatoprotective effects and potential antioxidant activity. However, its ability to alleviate acetaminophen-induced acute liver injury (AILI) has not been elucidated.<h4>Objective</h4>To explore the protective effect of the natural compound SMND-309 against AILI and the potential mechanism.<h4>Methods</h4>The AILI model was established using a mouse model and HepG2 cells for pathological evaluation and biochemical assays of mouse liver tissues to assess the level of liver injury. The effects of SMND-309","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T19:10:30.569Z","creation":"2026-05-19T03:07:12.329Z"},"accession":"S-EPMC11957308","cross_references":{"pubmed":["40163430"],"doi":["10.1371/journal.pone.0310879"]}}