biostudies-literatureUnknown197(11)Postill G<h4>Background</h4>Multimorbidity, the co-occurrence of 2 or more chronic conditions, is important in patients with inflammatory bowel disease (IBD) given its association with complex care plans, poor health outcomes, and excess mortality. Our objectives were to describe premature death (age < 75 yr) among people with IBD and to identify patterns between multimorbidity and premature death among decedents with IBD.<h4>Methods</h4>Using the administrative health data of people with IBD who died between 2010 and 2020 in Ontario, Canada, we conducted a population-based, retrospective cohort study. We described the proportion of premature deaths among people with IBD. We developed statistical and machine learning models to predict premature death from the presence of 17 chronic conditions and tCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienneE286-E297https://www.ebi.ac.uk/biostudies/studies/S-EPMC11957713biostudies-literatureMachine learning prediction of premature death from multimorbidity among people with inflammatory bowel disease: a population-based retrospective cohort study.PMC11957713Benchimol EIItanyi IUBuajitti EKuenzig MERosella LTang FHarish VPostill GfalseMachine learning prediction of premature death from multimorbidity among people with inflammatory bowel disease: a population-based retrospective cohort study.<h4>Background</h4>Multimorbidity, the co-occurrence of 2 or more chronic conditions, is important in patients with inflammatory bowel disease (IBD) given its association with complex care plans, poor health outcomes, and excess mortality. Our objectives were to describe premature death (age < 75 yr) among people with IBD and to identify patterns between multimorbidity and premature death among decedents with IBD.<h4>Methods</h4>Using the administrative health data of people with IBD who died between 2010 and 2020 in Ontario, Canada, we conducted a population-based, retrospective cohort study. We described the proportion of premature deaths among people with IBD. We developed statistical and machine learning models to predict premature death from the presence of 17 chronic conditions and t2025-01-01T00:00:00Z2025 Mar2025-07-04T03:05:44.129Z2025-07-04T03:05:44.129ZS-EPMC119577134012791610.1503/cmaj.241117