biostudies-literatureUnknown20(3)Teh JS<h4>Background</h4>Uncomplicated type B aortic dissections was regarded benign and treated with optimal medical therapy (OMT). However, studies showed highly unpredictable of disease progression, which suggested the need of earlier intervention. To search for features associated with worse outcomes with OMT is important due to risk of intervention. We investigated mortality and aortic remodeling between aggressive (OMT and pre-emptive endovascular intervention) and conservative therapy (OMT and necessary operations).<h4>Methods</h4>Retrospective analysis was performed in acute and subacute uncomplicated type B dissections patients, including typical aortic dissection, intramural hematoma and penetrating atherosclerotic ulcer, diagnosed between June 2005 and May 2021. Patients with Marfan, PloS onee0319561https://www.ebi.ac.uk/biostudies/studies/S-EPMC11957770biostudies-literatureInitial aortic repair versus medical therapy for early uncomplicated type B dissections.PMC11957770Teh JSHsu CPHuang CYShih CCKuo YTChen JHChen TWfalseInitial aortic repair versus medical therapy for early uncomplicated type B dissections.<h4>Background</h4>Uncomplicated type B aortic dissections was regarded benign and treated with optimal medical therapy (OMT). However, studies showed highly unpredictable of disease progression, which suggested the need of earlier intervention. To search for features associated with worse outcomes with OMT is important due to risk of intervention. We investigated mortality and aortic remodeling between aggressive (OMT and pre-emptive endovascular intervention) and conservative therapy (OMT and necessary operations).<h4>Methods</h4>Retrospective analysis was performed in acute and subacute uncomplicated type B dissections patients, including typical aortic dissection, intramural hematoma and penetrating atherosclerotic ulcer, diagnosed between June 2005 and May 2021. Patients with Marfan, 2025-01-01T00:00:00Z20252025-07-09T03:04:50.508Z2025-07-09T03:04:50.508ZS-EPMC119577704011198210.1371/journal.pone.0319561