biostudies-literatureUnknown15(1)Li CThis study aims to investigate the relationship between the triglyceride-glucose body mass index (TyG-BMI) and cardiovascular disease (CVD) among middle-aged and elderly women, using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. TyG-BMI was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2] × BMI. After applying the sampling weights from NHANES, the study sample of 6,343 participants is representative of approximately 59,174,898 American women. We categorized TyG-BMI into quartiles, using Q3 as the reference group. In the crude model, Q4 exhibited a 40% increased odds of CVD (odds ratio [OR] = 1.40, 95% confidence interval [CI] 1.09-1.79, P = 0.009). In the fully adjusted model, the increased odds of CVD for Q4Scientific reports10953https://www.ebi.ac.uk/biostudies/studies/S-EPMC11958736biostudies-literatureNonlinear relationships between the triglyceride glucose-body mass index and cardiovascular disease in middle-aged and elderly women from NHANES (1999-2018).PMC11958736Wan CLin QLi CLi LfalseNonlinear relationships between the triglyceride glucose-body mass index and cardiovascular disease in middle-aged and elderly women from NHANES (1999-2018).This study aims to investigate the relationship between the triglyceride-glucose body mass index (TyG-BMI) and cardiovascular disease (CVD) among middle-aged and elderly women, using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. TyG-BMI was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2] × BMI. After applying the sampling weights from NHANES, the study sample of 6,343 participants is representative of approximately 59,174,898 American women. We categorized TyG-BMI into quartiles, using Q3 as the reference group. In the crude model, Q4 exhibited a 40% increased odds of CVD (odds ratio [OR] = 1.40, 95% confidence interval [CI] 1.09-1.79, P = 0.009). In the fully adjusted model, the increased odds of CVD for Q42025-01-01T00:00:00Z2025 Mar2025-06-28T03:05:19.954Z2025-06-28T03:05:19.954ZS-EPMC119587364016475510.1038/s41598-025-95677-5