{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Neisch AL"],"funding":["NIA NIH HHS","University of Minnesota","National Institutes of Health","NIGMS NIH HHS","NIH HHS"],"pagination":["JCS263844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11959486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["138(5)"],"pubmed_abstract":["Cytoplasmic dynein is essential in motor neurons for retrograde cargo transport that sustains neuronal connectivity. Little, however, is known about dynein function on the postsynaptic side of the circuit. Here, we report distinct postsynaptic roles for dynein at neuromuscular junctions in Drosophila. Intriguingly, we show that dynein puncta accumulate postsynaptically at glutamatergic synaptic terminals. Moreover, Skittles (Sktl), a phosphatidylinositol 4-phosphate 5-kinase that produces phosphatidylinositol 4,5-bisphosphate (PIP2) to organize the spectrin cytoskeleton, also localizes specifically to glutamatergic synaptic terminals. Depletion of postsynaptic dynein disrupted the accumulation of Skittles and the PIP2 phospholipid, and organization of the spectrin cytoskeleton at the posts"],"journal":["Journal of cell science"],"pubmed_title":["Dynein-driven regulation of postsynaptic membrane architecture and synaptic function."],"pmcid":["PMC11959486"],"funding_grant_id":["R56 GM044757","AG078690","R01 GM044757","R21 AG078690","GM044757"],"pubmed_authors":["Li MG","Hays TS","Neisch AL","Avery AW","Pengo T"],"additional_accession":[]},"is_claimable":false,"name":"Dynein-driven regulation of postsynaptic membrane architecture and synaptic function.","description":"Cytoplasmic dynein is essential in motor neurons for retrograde cargo transport that sustains neuronal connectivity. Little, however, is known about dynein function on the postsynaptic side of the circuit. Here, we report distinct postsynaptic roles for dynein at neuromuscular junctions in Drosophila. Intriguingly, we show that dynein puncta accumulate postsynaptically at glutamatergic synaptic terminals. Moreover, Skittles (Sktl), a phosphatidylinositol 4-phosphate 5-kinase that produces phosphatidylinositol 4,5-bisphosphate (PIP2) to organize the spectrin cytoskeleton, also localizes specifically to glutamatergic synaptic terminals. Depletion of postsynaptic dynein disrupted the accumulation of Skittles and the PIP2 phospholipid, and organization of the spectrin cytoskeleton at the posts","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-05-29T17:25:53.131Z","creation":"2025-07-07T03:08:26.077Z"},"accession":"S-EPMC11959486","cross_references":{"pubmed":["39865922"],"doi":["10.1242/jcs.263844"]}}