biostudies-literatureKar DNational Institute for Health and Care Research168https://www.ebi.ac.uk/biostudies/studies/S-EPMC11959863biostudies-literatureUnknown26(1)<h4>Background</h4>The global prevalence of end-stage kidney disease (ESKD) is increasing despite optimal management of traditional risk factors such as hyperglycaemia, hypertension, and dyslipidaemia. This study examines the influence of cardiorenal risk factors, socioeconomic status, and ethnic and cardiovascular comorbidities on ESKD outcomes in the general population.<h4>Methods</h4>This cross-sectional study analysed data from 502,408 UK Biobank study participants recruited between 2006 and 2010. Multivariable logistic regression models were fitted to assess risk factors for ESKD, with results presented as adjusted odds ratio (aOR) and 95% confidence intervals (95% CI).<h4>Results</h4>A total of 1191 (0.2%) of the study participants reported ESKD. Diabetes increased ESKD risk by 62% [BMC nephrologyNavigating the complexities of end-stage kidney disease (ESKD) from risk factors to outcome: insights from the UK Biobank cohort.PMC11959863CL-2023-24-001Kar SIslam SSarker MHRde Lusignan SKadam UZabeen BSheikh AKar DVerma ANath MBanu SOrdonez-Mena JMAcharjee DEl-Wazir ASong SKhan NByng RAllgar VfalseNavigating the complexities of end-stage kidney disease (ESKD) from risk factors to outcome: insights from the UK Biobank cohort.<h4>Background</h4>The global prevalence of end-stage kidney disease (ESKD) is increasing despite optimal management of traditional risk factors such as hyperglycaemia, hypertension, and dyslipidaemia. This study examines the influence of cardiorenal risk factors, socioeconomic status, and ethnic and cardiovascular comorbidities on ESKD outcomes in the general population.<h4>Methods</h4>This cross-sectional study analysed data from 502,408 UK Biobank study participants recruited between 2006 and 2010. Multivariable logistic regression models were fitted to assess risk factors for ESKD, with results presented as adjusted odds ratio (aOR) and 95% confidence intervals (95% CI).<h4>Results</h4>A total of 1191 (0.2%) of the study participants reported ESKD. Diabetes increased ESKD risk by 62% [2025-01-01T00:00:00Z2025 Apr2025-07-11T03:03:54.631Z2025-07-11T03:03:54.631ZS-EPMC119598634016995210.1186/s12882-025-04090-7