biostudies-literatureKnisely ANCI NIH HHSUniversity of Texas MD Anderson Cancer Center326.e1-326.e13https://www.ebi.ac.uk/biostudies/studies/S-EPMC11961129biostudies-literatureUnknown231(3)<h4>Background</h4>Surgical site infection is one of the most common complications of gynecologic cancer surgery. Current guidelines recommend the administration of cefazolin preoperatively to reduce surgical site infection rates for patients undergoing clean-contaminated surgeries such as hysterectomy.<h4>Objective</h4>To evaluate the impact of a quality improvement project adding metronidazole to cefazolin for antibiotic prophylaxis on surgical site infection rate for women undergoing gynecologic surgery at a comprehensive cancer center.<h4>Study design</h4>This retrospective, single-center cohort study included patients who underwent surgery in the gynecologic oncology department from May 2017 to June 2023. Patients with penicillin allergies and those undergoing concomitant bowel resectAmerican journal of obstetrics and gynecologyMetronidazole and cefazolin vs cefazolin alone for surgical site infection prophylaxis in gynecologic surgery at a comprehensive cancer center.PMC11961129T32 CA101642P30 CA016672CA101642Taylor JSSchmeler KMChisholm GKnisely AIniesta MDMarten CAfalseMetronidazole and cefazolin vs cefazolin alone for surgical site infection prophylaxis in gynecologic surgery at a comprehensive cancer center.<h4>Background</h4>Surgical site infection is one of the most common complications of gynecologic cancer surgery. Current guidelines recommend the administration of cefazolin preoperatively to reduce surgical site infection rates for patients undergoing clean-contaminated surgeries such as hysterectomy.<h4>Objective</h4>To evaluate the impact of a quality improvement project adding metronidazole to cefazolin for antibiotic prophylaxis on surgical site infection rate for women undergoing gynecologic surgery at a comprehensive cancer center.<h4>Study design</h4>This retrospective, single-center cohort study included patients who underwent surgery in the gynecologic oncology department from May 2017 to June 2023. Patients with penicillin allergies and those undergoing concomitant bowel resect2024-01-01T00:00:00Z2024 Sep2025-07-14T03:02:26.206Z2025-07-14T03:02:26.206ZS-EPMC119611293859947810.1016/j.ajog.2024.03.043