{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Petrohilos C"],"funding":["Australian Research Council"],"pagination":["e70091"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11961399"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(4)"],"pubmed_abstract":["Contagious cancers represent one of the least understood types of infections in wildlife. Devil Facial Tumor Disease (comprised of two different contagious cancers, DFT1 and DFT2) has led to an 80% decline in the Tasmanian devil (<i>Sarcophilus harrisii</i> ) population at the regional level since it was first observed in 1996. There are currently no treatment options for the disease, and research efforts are focused on vaccine development. Although DFT1 is clonal, phylogenomic studies have identified different genetic variants of the pathogen. We postulated that different genetic strains may have different gene expression profiles and would therefore require different vaccine components. Here, we aimed to test this hypothesis by applying two types of unsupervised clustering (hierarchical "],"journal":["Evolutionary applications"],"pubmed_title":["No Evidence for Distinct Transcriptomic Subgroups of Devil Facial Tumor Disease (DFTD)."],"pmcid":["PMC11961399"],"funding_grant_id":["LP180100244","CE200100012"],"pubmed_authors":["Belov K","Peel E","Hogg CJ","Batley KC","Petrohilos C","Fox S"],"additional_accession":[]},"is_claimable":false,"name":"No Evidence for Distinct Transcriptomic Subgroups of Devil Facial Tumor Disease (DFTD).","description":"Contagious cancers represent one of the least understood types of infections in wildlife. Devil Facial Tumor Disease (comprised of two different contagious cancers, DFT1 and DFT2) has led to an 80% decline in the Tasmanian devil (<i>Sarcophilus harrisii</i> ) population at the regional level since it was first observed in 1996. There are currently no treatment options for the disease, and research efforts are focused on vaccine development. Although DFT1 is clonal, phylogenomic studies have identified different genetic variants of the pathogen. We postulated that different genetic strains may have different gene expression profiles and would therefore require different vaccine components. Here, we aimed to test this hypothesis by applying two types of unsupervised clustering (hierarchical ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T14:33:51.064Z","creation":"2026-04-08T13:24:26.59Z"},"accession":"S-EPMC11961399","cross_references":{"pubmed":["40177324"],"doi":["10.1111/eva.70091"]}}