biostudies-literatureUnknown77(2)Emile SHPelvic exenteration (PE) entails an en bloc resection of locally advanced primary or recurrent rectal cancer. This study aimed to assess the short-term and survival outcomes of minimally invasive (MI)- and open PE. A retrospective cohort analysis of patients with stage III rectal adenocarcinoma treated with PE from the National Cancer Database (2010-2019) was conducted. Open and MI-PE were matched for baseline and treatment characteristics using 2:1 propensity score matching. Primary outcomes were 30- and 90-day mortality; secondary outcomes included 30-day readmission, hospital stay, surgical margins, lymph node yield, and overall survival (OS). PE was performed in 1010 (1.9%) of 52,242 patients; 705 (69.8%) were open and 304 were (30.2%) MI procedures. After matching, 169 patients in theUpdates in surgery267-276https://www.ebi.ac.uk/biostudies/studies/S-EPMC11961522biostudies-literaturePropensity-score matched outcomes of minimally invasive and open pelvic exenteration in locally advanced rectal cancer.PMC11961522Gefen RHoresh NDourado JWexner SDEmile SHGaroufalia ZSalama EfalsePropensity-score matched outcomes of minimally invasive and open pelvic exenteration in locally advanced rectal cancer.Pelvic exenteration (PE) entails an en bloc resection of locally advanced primary or recurrent rectal cancer. This study aimed to assess the short-term and survival outcomes of minimally invasive (MI)- and open PE. A retrospective cohort analysis of patients with stage III rectal adenocarcinoma treated with PE from the National Cancer Database (2010-2019) was conducted. Open and MI-PE were matched for baseline and treatment characteristics using 2:1 propensity score matching. Primary outcomes were 30- and 90-day mortality; secondary outcomes included 30-day readmission, hospital stay, surgical margins, lymph node yield, and overall survival (OS). PE was performed in 1010 (1.9%) of 52,242 patients; 705 (69.8%) were open and 304 were (30.2%) MI procedures. After matching, 169 patients in the2025-01-01T00:00:00Z2025 Apr2025-06-28T03:05:09.328Z2025-06-28T03:05:09.328ZS-EPMC119615223982160010.1007/s13304-025-02102-7