{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Joyce OC"],"pubmed_abstract":["Introduction
Several measures of cardiovascular health have been investigated as potential risk factors for development of cognitive decline in mid-to later-life, among them, circulating cholesterol. However, the efficacy of midlife interventions aimed at reducing blood cholesterol to mitigate the risk of cognitive decline is uncertain, with conflicting evidence reported from a range of longitudinal and cross-sectional studies. This review systematically investigates the connection between cholesterol measures in midlife and their impact on cognitive function in both mid- and later-life.Methods
Electronic databases were explored from their inception until December 2023. Studies that evaluated the relationship between cholesterol and its sub-components in midlife (40-65 year"],"journal":["Frontiers in aging"],"pagination":["1430382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11962029"],"repository":["biostudies-literature"],"pubmed_title":["The influence of circulating cholesterol and its components in middle-aged adults on cognitive function at mid- and later-life; a systematic review."],"pmcid":["PMC11962029"],"pubmed_authors":["McHugh C","Wilson F","Joyce OC","Mockler D","Kelly AM"],"additional_accession":[]},"is_claimable":false,"name":"The influence of circulating cholesterol and its components in middle-aged adults on cognitive function at mid- and later-life; a systematic review.","description":"Introduction
Several measures of cardiovascular health have been investigated as potential risk factors for development of cognitive decline in mid-to later-life, among them, circulating cholesterol. However, the efficacy of midlife interventions aimed at reducing blood cholesterol to mitigate the risk of cognitive decline is uncertain, with conflicting evidence reported from a range of longitudinal and cross-sectional studies. This review systematically investigates the connection between cholesterol measures in midlife and their impact on cognitive function in both mid- and later-life.Methods
Electronic databases were explored from their inception until December 2023. Studies that evaluated the relationship between cholesterol and its sub-components in midlife (40-65 year","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-11T03:04:01.559Z","creation":"2025-07-11T03:04:01.559Z"},"accession":"S-EPMC11962029","cross_references":{"pubmed":["40177626"],"doi":["10.3389/fragi.2025.1430382"]}}