biostudies-literatureUnknown6Joyce OC<h4>Introduction</h4>Several measures of cardiovascular health have been investigated as potential risk factors for development of cognitive decline in mid-to later-life, among them, circulating cholesterol. However, the efficacy of midlife interventions aimed at reducing blood cholesterol to mitigate the risk of cognitive decline is uncertain, with conflicting evidence reported from a range of longitudinal and cross-sectional studies. This review systematically investigates the connection between cholesterol measures in midlife and their impact on cognitive function in both mid- and later-life.<h4>Methods</h4>Electronic databases were explored from their inception until December 2023. Studies that evaluated the relationship between cholesterol and its sub-components in midlife (40-65 yearFrontiers in aging1430382https://www.ebi.ac.uk/biostudies/studies/S-EPMC11962029biostudies-literatureThe influence of circulating cholesterol and its components in middle-aged adults on cognitive function at mid- and later-life; a systematic review.PMC11962029McHugh CWilson FJoyce OCMockler DKelly AMfalseThe influence of circulating cholesterol and its components in middle-aged adults on cognitive function at mid- and later-life; a systematic review.<h4>Introduction</h4>Several measures of cardiovascular health have been investigated as potential risk factors for development of cognitive decline in mid-to later-life, among them, circulating cholesterol. However, the efficacy of midlife interventions aimed at reducing blood cholesterol to mitigate the risk of cognitive decline is uncertain, with conflicting evidence reported from a range of longitudinal and cross-sectional studies. This review systematically investigates the connection between cholesterol measures in midlife and their impact on cognitive function in both mid- and later-life.<h4>Methods</h4>Electronic databases were explored from their inception until December 2023. Studies that evaluated the relationship between cholesterol and its sub-components in midlife (40-65 year2025-01-01T00:00:00Z20252025-07-11T03:04:01.559Z2025-07-11T03:04:01.559ZS-EPMC119620294017762610.3389/fragi.2025.1430382