{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi V"],"funding":["Engineering and Physical Sciences Research Council"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11962098"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["Chronic infections represent a major clinical challenge due to the enhanced antimicrobial tolerance of biofilm-dwelling bacteria. To address this challenge, an ultrasound-responsive nanoscale drug delivery platform (nanodroplets) is presented in this work, loaded with four different antimicrobial agents, capable of simultaneous biofilm disruption and targeted antimicrobial delivery. When loaded, a robust protective effect against clinically-derived MRSA and ESBL Gram-positive and Gram-negative planktonic isolates was shown in vitro. Upon application of therapeutic ultrasound, an average 7.6-fold, 44.4-fold, and 25.5-fold reduction was observed in the antibiotic concentrations compared to free drug required to reach the MBC, MBEC and complete persister eradication levels, respectively. Nano"],"journal":["npj antimicrobials and resistance"],"pubmed_title":["Repurposing antimicrobials with ultrasound-triggered nanoscale systems for targeted biofilm drug delivery."],"pmcid":["PMC11962098"],"funding_grant_id":["EP/V026623/1"],"pubmed_authors":["Choi V","Carugo D","Stride E"],"additional_accession":[]},"is_claimable":false,"name":"Repurposing antimicrobials with ultrasound-triggered nanoscale systems for targeted biofilm drug delivery.","description":"Chronic infections represent a major clinical challenge due to the enhanced antimicrobial tolerance of biofilm-dwelling bacteria. To address this challenge, an ultrasound-responsive nanoscale drug delivery platform (nanodroplets) is presented in this work, loaded with four different antimicrobial agents, capable of simultaneous biofilm disruption and targeted antimicrobial delivery. When loaded, a robust protective effect against clinically-derived MRSA and ESBL Gram-positive and Gram-negative planktonic isolates was shown in vitro. Upon application of therapeutic ultrasound, an average 7.6-fold, 44.4-fold, and 25.5-fold reduction was observed in the antibiotic concentrations compared to free drug required to reach the MBC, MBEC and complete persister eradication levels, respectively. Nano","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-15T14:39:24.349Z","creation":"2025-06-28T03:05:21.795Z"},"accession":"S-EPMC11962098","cross_references":{"pubmed":["40169915"],"doi":["10.1038/s44259-025-00086-3"]}}