{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boddaert M"],"funding":["Agence Nationale de la Recherche"],"pagination":["e202403701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11962350"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(19)"],"pubmed_abstract":["The sulfur-containing chemical warfare agents sulfur mustard HD and nerve agent VX are highly toxic and persistent in the environment. Therefore, their neutralisation requires harsh oxidation conditions, but also precise selectivity. Here we report the safe and effective detoxification of surrogates CEES and PhX by selective oxidation of the sulfur atom by generating peracetic acid from AcOEt and aq. H<sub>2</sub>O<sub>2</sub> assisted by the supported lipase CALB. Morever, it is possible to perform these neutralisations with safe 'on demand' generation of AcOOH in a flow system by using a packed bed reactor containing the supported biocatalyst."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Oxidative Neutralisation of Sulfur-Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor."],"pmcid":["PMC11962350"],"funding_grant_id":["Labex SynOrg (ANR-11-LABX-0029)"],"pubmed_authors":["Mansour S","Monbaliu JM","Boddaert M","Baptista da Silva V","Renard PY","Vuluga D","Legros J"],"additional_accession":[]},"is_claimable":false,"name":"Oxidative Neutralisation of Sulfur-Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor.","description":"The sulfur-containing chemical warfare agents sulfur mustard HD and nerve agent VX are highly toxic and persistent in the environment. Therefore, their neutralisation requires harsh oxidation conditions, but also precise selectivity. Here we report the safe and effective detoxification of surrogates CEES and PhX by selective oxidation of the sulfur atom by generating peracetic acid from AcOEt and aq. H<sub>2</sub>O<sub>2</sub> assisted by the supported lipase CALB. Morever, it is possible to perform these neutralisations with safe 'on demand' generation of AcOOH in a flow system by using a packed bed reactor containing the supported biocatalyst.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-06-28T03:05:12.887Z","creation":"2025-06-28T03:05:12.887Z"},"accession":"S-EPMC11962350","cross_references":{"pubmed":["39757127"],"doi":["10.1002/chem.202403701"]}}