{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sahasrabuddhe AA"],"funding":["National Institutes of Health (NIH)","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["838-861"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11962402"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(4)"],"pubmed_abstract":["<h4>Significance</h4>We describe the identification of a previously unrecognized ubiquitin ligase-substrate (FBXO45-GEF-H1) regulatory axis that plays an important role in germinal center formation and pathogenesis of common BCLs. These studies reveal novel insights linking dysregulated ubiquitin-mediated control to exploitable vulnerabilities and novel therapeutic strategies for these cancers."],"journal":["Cancer discovery"],"pubmed_title":["The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis."],"pmcid":["PMC11962402"],"funding_grant_id":["P30 CA008748","R01 CA231021","R35 GM136250","R01CA231021","R01 HL123899"],"pubmed_authors":["Pillai V","Siebert R","Rottapel R","Hogaboam CM","Sahasrabuddhe AA","Kim J","Raabe TD","Morin RD","McFetridge C","Schlesner M","Onder O","Bailey NG","Liang HC","Basrur V","Lopez C","Wu R","Chen X","Li MM","Moro L","Szankasi P","Elenitoba-Johnson KSJ","Chhipa RR","Kapoor R","Dreval K","Morrissette JJD","Staudt LM","Conlon KP","Pagano M","Zhang X","Ma K","Lim MS","Van Arnam JS"],"additional_accession":[]},"is_claimable":false,"name":"The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis.","description":"<h4>Significance</h4>We describe the identification of a previously unrecognized ubiquitin ligase-substrate (FBXO45-GEF-H1) regulatory axis that plays an important role in germinal center formation and pathogenesis of common BCLs. These studies reveal novel insights linking dysregulated ubiquitin-mediated control to exploitable vulnerabilities and novel therapeutic strategies for these cancers.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-04-08T19:51:25.352Z","creation":"2026-04-08T14:30:07.747Z"},"accession":"S-EPMC11962402","cross_references":{"pubmed":["39820335"],"doi":["10.1158/2159-8290.CD-24-0442"]}}