biostudies-literatureSahasrabuddhe AANational Institutes of Health (NIH)NHLBI NIH HHSNCI NIH HHSNational Institutes of HealthNIGMS NIH HHS838-861https://www.ebi.ac.uk/biostudies/studies/S-EPMC11962402biostudies-literatureUnknown15(4)<h4>Significance</h4>We describe the identification of a previously unrecognized ubiquitin ligase-substrate (FBXO45-GEF-H1) regulatory axis that plays an important role in germinal center formation and pathogenesis of common BCLs. These studies reveal novel insights linking dysregulated ubiquitin-mediated control to exploitable vulnerabilities and novel therapeutic strategies for these cancers.Cancer discoveryThe FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis.PMC11962402P30 CA008748R01 CA231021R35 GM136250R01CA231021R01 HL123899Pillai VSiebert RRottapel RHogaboam CMSahasrabuddhe AAKim JRaabe TDMorin RDMcFetridge CSchlesner MOnder OBailey NGLiang HCBasrur VLopez CWu RChen XLi MMMoro LSzankasi PElenitoba-Johnson KSJChhipa RRKapoor RDreval KMorrissette JJDStaudt LMConlon KPPagano MZhang XMa KLim MSVan Arnam JSfalseThe FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis.<h4>Significance</h4>We describe the identification of a previously unrecognized ubiquitin ligase-substrate (FBXO45-GEF-H1) regulatory axis that plays an important role in germinal center formation and pathogenesis of common BCLs. These studies reveal novel insights linking dysregulated ubiquitin-mediated control to exploitable vulnerabilities and novel therapeutic strategies for these cancers.2025-01-01T00:00:00Z2025 Apr2026-04-08T19:51:25.352Z2026-04-08T14:30:07.747ZS-EPMC119624023982033510.1158/2159-8290.CD-24-0442