{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sommer F"],"funding":["Deutsche Forschungsgemeinschaft","Universitätsklinikum Schleswig-Holstein - Campus Kiel"],"pagination":["91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11963433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla. Recent findings, which have been derived mostly in simple animal models, have even established a causal relationship between age-related microbial shifts and lifespan, suggesting microbiota-directed interventions as a potential tool to decelerate aging processes. To test whether a life-long microbiome rejuvenation strategy could delay or even prevent aging in non-ruminant mammals, we performed recurrent fecal microbial transfer (FMT) in mice throughout life. Transfer material was either derived from 8-week-old mice (young microbiome, yMB) or from animals of the same age as the recipients (isochronic microbiome, iMB) as c"],"journal":["Microbiome"],"pubmed_title":["Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice."],"pmcid":["PMC11963433"],"funding_grant_id":["miTARGET","SO1141/10-1","CRC1182"],"pubmed_authors":["Bernardes JP","Fazio A","Kadibalban AS","Hamm J","Rosenstiel P","Sommer F","Lopez-Agudelo VA","Ito G","Sommer N","Marinos G","Best L","Messner B","Falk-Paulsen M","Kaleta C"],"additional_accession":[]},"is_claimable":false,"name":"Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice.","description":"<h4>Background</h4>Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla. Recent findings, which have been derived mostly in simple animal models, have even established a causal relationship between age-related microbial shifts and lifespan, suggesting microbiota-directed interventions as a potential tool to decelerate aging processes. To test whether a life-long microbiome rejuvenation strategy could delay or even prevent aging in non-ruminant mammals, we performed recurrent fecal microbial transfer (FMT) in mice throughout life. Transfer material was either derived from 8-week-old mice (young microbiome, yMB) or from animals of the same age as the recipients (isochronic microbiome, iMB) as c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-07T03:09:30.152Z","creation":"2025-07-07T03:09:30.152Z"},"accession":"S-EPMC11963433","cross_references":{"pubmed":["40176137"],"doi":["10.1186/s40168-025-02089-8"]}}