biostudies-literatureSommer FDeutsche ForschungsgemeinschaftUniversitätsklinikum Schleswig-Holstein - Campus Kiel91https://www.ebi.ac.uk/biostudies/studies/S-EPMC11963433biostudies-literatureUnknown13(1)<h4>Background</h4>Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla. Recent findings, which have been derived mostly in simple animal models, have even established a causal relationship between age-related microbial shifts and lifespan, suggesting microbiota-directed interventions as a potential tool to decelerate aging processes. To test whether a life-long microbiome rejuvenation strategy could delay or even prevent aging in non-ruminant mammals, we performed recurrent fecal microbial transfer (FMT) in mice throughout life. Transfer material was either derived from 8-week-old mice (young microbiome, yMB) or from animals of the same age as the recipients (isochronic microbiome, iMB) as cMicrobiomeLife-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice.PMC11963433miTARGETSO1141/10-1CRC1182Bernardes JPFazio AKadibalban ASHamm JRosenstiel PSommer FLopez-Agudelo VAIto GSommer NMarinos GBest LMessner BFalk-Paulsen MKaleta CfalseLife-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice.<h4>Background</h4>Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla. Recent findings, which have been derived mostly in simple animal models, have even established a causal relationship between age-related microbial shifts and lifespan, suggesting microbiota-directed interventions as a potential tool to decelerate aging processes. To test whether a life-long microbiome rejuvenation strategy could delay or even prevent aging in non-ruminant mammals, we performed recurrent fecal microbial transfer (FMT) in mice throughout life. Transfer material was either derived from 8-week-old mice (young microbiome, yMB) or from animals of the same age as the recipients (isochronic microbiome, iMB) as c2025-01-01T00:00:00Z2025 Apr2025-07-07T03:09:30.152Z2025-07-07T03:09:30.152ZS-EPMC119634334017613710.1186/s40168-025-02089-8