{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng A"],"funding":["NCATS NIH HHS","NEI NIH HHS","NIDCD NIH HHS"],"pagination":["452-460"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11964604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(2)"],"pubmed_abstract":["We have developed sustained Dex (dexamethasone) capsule implants for sustained local delivery for inflammatory disease treatment. Four different biodegradable polymers were used as capsule materials: polycaprolactone (PCL), poly(lactic acid) (PLA), 90 : 10 poly(lactic-co-glycolide) (PLGA), and 50 : 50 PLGA. The drug release profiles from the four types of capsule were compared and the profiles were fit to a cylindrical reservoir first-order kinetics model. As a result, 50 : 50 PLGA showed the fastest release with the largest permeability and partition coefficient at 0.4909 nm/s and 1.9519, respectively. On the other hand, PCL showed the slowest release with the smallest permeability and partition coefficient at 0.1915 nm/s and 0.8872, respectively. The results indicate that the drug releas"],"journal":["The Korean journal of chemical engineering"],"pubmed_title":["Biodegradable dexamethasone polymer capsule for long-term release."],"pmcid":["PMC11964604"],"funding_grant_id":["R21 DC021038","R15 EY031500","R03 TR004429"],"pubmed_authors":["Debele T","Park Y","Zheng A","Dion G","Waterkotte T"],"additional_accession":[]},"is_claimable":false,"name":"Biodegradable dexamethasone polymer capsule for long-term release.","description":"We have developed sustained Dex (dexamethasone) capsule implants for sustained local delivery for inflammatory disease treatment. Four different biodegradable polymers were used as capsule materials: polycaprolactone (PCL), poly(lactic acid) (PLA), 90 : 10 poly(lactic-co-glycolide) (PLGA), and 50 : 50 PLGA. The drug release profiles from the four types of capsule were compared and the profiles were fit to a cylindrical reservoir first-order kinetics model. As a result, 50 : 50 PLGA showed the fastest release with the largest permeability and partition coefficient at 0.4909 nm/s and 1.9519, respectively. On the other hand, PCL showed the slowest release with the smallest permeability and partition coefficient at 0.1915 nm/s and 0.8872, respectively. The results indicate that the drug releas","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-07-14T03:02:33.843Z","creation":"2025-07-14T03:02:33.843Z"},"accession":"S-EPMC11964604","cross_references":{"pubmed":["40177070"],"doi":["10.1007/s11814-022-1358-y"]}}