biostudies-literatureZheng ANCATS NIH HHSNEI NIH HHSNIDCD NIH HHS452-460https://www.ebi.ac.uk/biostudies/studies/S-EPMC11964604biostudies-literatureUnknown40(2)We have developed sustained Dex (dexamethasone) capsule implants for sustained local delivery for inflammatory disease treatment. Four different biodegradable polymers were used as capsule materials: polycaprolactone (PCL), poly(lactic acid) (PLA), 90 : 10 poly(lactic-co-glycolide) (PLGA), and 50 : 50 PLGA. The drug release profiles from the four types of capsule were compared and the profiles were fit to a cylindrical reservoir first-order kinetics model. As a result, 50 : 50 PLGA showed the fastest release with the largest permeability and partition coefficient at 0.4909 nm/s and 1.9519, respectively. On the other hand, PCL showed the slowest release with the smallest permeability and partition coefficient at 0.1915 nm/s and 0.8872, respectively. The results indicate that the drug releasThe Korean journal of chemical engineeringBiodegradable dexamethasone polymer capsule for long-term release.PMC11964604R21 DC021038R15 EY031500R03 TR004429Debele TPark YZheng ADion GWaterkotte TfalseBiodegradable dexamethasone polymer capsule for long-term release.We have developed sustained Dex (dexamethasone) capsule implants for sustained local delivery for inflammatory disease treatment. Four different biodegradable polymers were used as capsule materials: polycaprolactone (PCL), poly(lactic acid) (PLA), 90 : 10 poly(lactic-co-glycolide) (PLGA), and 50 : 50 PLGA. The drug release profiles from the four types of capsule were compared and the profiles were fit to a cylindrical reservoir first-order kinetics model. As a result, 50 : 50 PLGA showed the fastest release with the largest permeability and partition coefficient at 0.4909 nm/s and 1.9519, respectively. On the other hand, PCL showed the slowest release with the smallest permeability and partition coefficient at 0.1915 nm/s and 0.8872, respectively. The results indicate that the drug releas2023-01-01T00:00:00Z2023 Feb2025-07-14T03:02:33.843Z2025-07-14T03:02:33.843ZS-EPMC119646044017707010.1007/s11814-022-1358-y