biostudies-literatureSong LDiscipline construction funds of Shanxi University of Chinese MedicineScience and Technology Innovation Team Project of Shanxi University of Chinese MedicineScience and Technology Cooperation and Exchange Special Project of Shanxi Province in 2023Shanxi University of Chinese Medicine Science and Technology Innovation Capability Cultivation Plan National Natural Science Foundation Cultivation Special ProjectCardiovascular Special Fund Project of The National Regional Medical Center of Traditional Chinese Medicine and Affiliated Hospital of Shanxi University of Chinese MedicineChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaShanxi Science and Technology Innovation Young team ProjectZhang Zhongjing inheritance and Innovation Project of State Administration of Traditional Chinese Medicine161https://www.ebi.ac.uk/biostudies/studies/S-EPMC11965183biostudies-literatureUnknown40(4)Lipocalin-2 (LCN2), an acute phase protein mainly expressed in astrocytes (Ast), is closely related to the production of inflammatory cytokines following ischemic stroke. During the pathophysiological process of ischemic stroke, the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway is activated. Despite evidence suggesting some link between the two, the relationship between the JAK2/STAT3 signaling pathway and the LCN2 expression in Ast following brain ischemia is incompletely understood. Hydroxysafflower yellow A (HSYA), an active ingredient found in Carthamus tinctorius L flowers, has been demonstrated to effectively mitigate cerebral ischemia via its anti-inflammatory effect. However, whether HSYA mitigates the neuroinflammatory damage afteMetabolic brain diseaseHydroxysafflower yellow A alleviates the inflammatory response in astrocytes following cerebral ischemia by inhibiting the LCN2/STAT3 feedback loop.PMC119651832022040510010282024XKJS-02820040282022TD2010XGZX202115202304041101004GZY-KJS-2022-048-12020M6809122024PY-NS-012Song LHua JLiu KMa CMa DZhang CYin LWu YRong MXiao BDuan YYin JfalseHydroxysafflower yellow A alleviates the inflammatory response in astrocytes following cerebral ischemia by inhibiting the LCN2/STAT3 feedback loop.Lipocalin-2 (LCN2), an acute phase protein mainly expressed in astrocytes (Ast), is closely related to the production of inflammatory cytokines following ischemic stroke. During the pathophysiological process of ischemic stroke, the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway is activated. Despite evidence suggesting some link between the two, the relationship between the JAK2/STAT3 signaling pathway and the LCN2 expression in Ast following brain ischemia is incompletely understood. Hydroxysafflower yellow A (HSYA), an active ingredient found in Carthamus tinctorius L flowers, has been demonstrated to effectively mitigate cerebral ischemia via its anti-inflammatory effect. However, whether HSYA mitigates the neuroinflammatory damage afte2025-01-01T00:00:00Z2025 Mar2025-07-12T03:04:37.428Z2025-07-12T03:04:37.428ZS-EPMC119651834017258410.1007/s11011-025-01581-2