{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Getu MA"],"funding":["Shenzhen Key Medical Discipline Construction Fund & Sanming Project of Medicine in Shenzhen","Shenzhen Key Medical Discipline Construction Fund & Sanming Project of Medicine in Shenzhen","National Natural Science Foundation of China","Medicine-Engineering Interdisciplinary Research Foundation of Shenzhen University","Shenzhen Science and Technology Program"],"pagination":["11371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11965372"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Previous observational studies have suggested a potential link between Type 1 Diabetes (T1D) and site-specific cancer risk. However, the nature of this association remains uncertain due to confounding factors, reverse causation, and biases inherent in observational research. To address this gap, we conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between T1D and 22 site-specific cancers. Using summary statistics from large-scale genome-wide association studies of European ancestry, comprising data on T1D (N = 520,580) and the 22 site-specific cancers, we selected single nucleotide polymorphisms strongly associated with T1D as instruments for our analysis. Causal relationships were primarily evaluated through inverse-variance weighting-based analys"],"journal":["Scientific reports"],"pubmed_title":["A two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers."],"pmcid":["PMC11965372"],"funding_grant_id":["GJHZ20220913143005010","2023YG019","SZSM202111002","82104596"],"pubmed_authors":["Gong P","Zhang X","Ying Y","Getu MA"],"additional_accession":[]},"is_claimable":false,"name":"A two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers.","description":"Previous observational studies have suggested a potential link between Type 1 Diabetes (T1D) and site-specific cancer risk. However, the nature of this association remains uncertain due to confounding factors, reverse causation, and biases inherent in observational research. To address this gap, we conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between T1D and 22 site-specific cancers. Using summary statistics from large-scale genome-wide association studies of European ancestry, comprising data on T1D (N = 520,580) and the 22 site-specific cancers, we selected single nucleotide polymorphisms strongly associated with T1D as instruments for our analysis. Causal relationships were primarily evaluated through inverse-variance weighting-based analys","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-06-28T03:05:21.681Z","creation":"2025-06-28T03:05:21.681Z"},"accession":"S-EPMC11965372","cross_references":{"pubmed":["40175445"],"doi":["10.1038/s41598-025-89288-3"]}}