{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Mercanoglu B"],"funding":["Universitätsklinikum Hamburg-Eppendorf (UKE)"],"pubmed_abstract":["Altered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) has also been implicated in numerous diseases. We generated a transgenic mouse model with conditional Cosmc-knockout and simultaneous overexpression of polypeptide N-acetylgalactosaminyltransferase 2 (GalNT2) mediated by the pancreas-specific transcription factor 1a (Ptf1a)-Cre mouse strain to investigate the effect of Tn antigen overexpression on the pancreas in vivo. Histopathological examination of the transgenic pancreas revealed a chronic pancreatitis phenotype with interlobular fibrosis and focal necrosis after"],"journal":["Scientific reports"],"pagination":["11306"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11965491"],"repository":["biostudies-literature"],"pubmed_title":["Overexpression of Tn antigen induces chronic pancreatitis in mice."],"pmcid":["PMC11965491"],"pubmed_authors":["Wolters-Eisfeld G","Neuburg E","Kempski J","Bockhorn M","Mercanoglu B","Schraps N","Giannou AD","Wagener C","Melling N","Hackert T"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of Tn antigen induces chronic pancreatitis in mice.","description":"Altered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) has also been implicated in numerous diseases. We generated a transgenic mouse model with conditional Cosmc-knockout and simultaneous overexpression of polypeptide N-acetylgalactosaminyltransferase 2 (GalNT2) mediated by the pancreas-specific transcription factor 1a (Ptf1a)-Cre mouse strain to investigate the effect of Tn antigen overexpression on the pancreas in vivo. Histopathological examination of the transgenic pancreas revealed a chronic pancreatitis phenotype with interlobular fibrosis and focal necrosis after","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-14T03:03:05.434Z","creation":"2025-07-14T03:03:05.434Z"},"accession":"S-EPMC11965491","cross_references":{"pubmed":["40175689"],"doi":["10.1038/s41598-025-96060-0"]}}