biostudies-literatureUnknown16Wu RZ<h4>Background</h4>Lung adenocarcinoma (LUAD) is one of the most common malignant tumors globally, characterized by poor prognosis and high mortality. Abnormal fatty acid metabolism plays a crucial role in LUAD progression. This study aims to develop a prognostic model based on fatty acid metabolism to improve the overall prognosis of LUAD.<h4>Materials and methods</h4>Bioinformatics analyses were performed using TCGA and GEO datasets, supplemented by cell experiments. A total of 309 fatty acid metabolism-related genes were identified from MsigDB. Differentially expressed genes were analyzed using the 'limma' R package. A prognostic model was constructed using LASSO regression and validated with survival analyses via the 'survminer', 'survival', and 'pROC' R packages. The analysis includedFrontiers in immunology1507845https://www.ebi.ac.uk/biostudies/studies/S-EPMC11965909biostudies-literatureFatty acid metabolism-derived prognostic model for lung adenocarcinoma: unraveling the link to survival and immune response.PMC11965909Sun QQYu HNRui XWu RZLiu WYZhang HFu YPan YLWu YHfalseFatty acid metabolism-derived prognostic model for lung adenocarcinoma: unraveling the link to survival and immune response.<h4>Background</h4>Lung adenocarcinoma (LUAD) is one of the most common malignant tumors globally, characterized by poor prognosis and high mortality. Abnormal fatty acid metabolism plays a crucial role in LUAD progression. This study aims to develop a prognostic model based on fatty acid metabolism to improve the overall prognosis of LUAD.<h4>Materials and methods</h4>Bioinformatics analyses were performed using TCGA and GEO datasets, supplemented by cell experiments. A total of 309 fatty acid metabolism-related genes were identified from MsigDB. Differentially expressed genes were analyzed using the 'limma' R package. A prognostic model was constructed using LASSO regression and validated with survival analyses via the 'survminer', 'survival', and 'pROC' R packages. The analysis included2025-01-01T00:00:00Z20252026-06-02T21:06:05.59Z2025-06-26T03:06:13.586ZS-EPMC119659094018197610.3389/fimmu.2025.1507845