{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Fundamental Research Funds for the Central Universities","Hubei Hongshan Laboratory Fund","National Science Fund for Distinguished Young Scholars","HZAU-AGIS Cooperation Fund","National Natural Science Foundation of China","Biological Breeding-National Science and Technology Major Project"],"pagination":["83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11966889"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>The fatty acid content represents a crucial quality trait in Brassica napus or rapeseed. Improvements in fatty acid composition markedly enhance the quality of rapeseed oil.<h4>Results</h4>Here, we perform a genome-wide association study (GWAS) to identify quantitative trait locus (QTLs) associated with fatty acid content. We identify a total of seven stable QTLs and find two loci, qFA.A08 and qFA.A09.1, subjected to strong selection pressure. By transcriptome-wide association analysis (TWAS), we characterize 3295 genes that are significantly correlated with the composition of at least one fatty acid. To elucidate the genetic underpinnings governing fatty acid composition, we then employ a combination of GWAS, TWAS, and dynamic transcriptomic analysis during seed develop"],"journal":["Genome biology"],"pubmed_title":["Integrative omics analysis reveals the genetic basis of fatty acid composition in Brassica napus seeds."],"pmcid":["PMC11966889"],"funding_grant_id":["32225037","SZYJY2021004","U2102217","2023ZD04069","X2662024ZKPY001","2021HSZD004"],"pubmed_authors":["Liu Y","Guo L","Zhang Y","Zong Z","Shen W","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Integrative omics analysis reveals the genetic basis of fatty acid composition in Brassica napus seeds.","description":"<h4>Background</h4>The fatty acid content represents a crucial quality trait in Brassica napus or rapeseed. Improvements in fatty acid composition markedly enhance the quality of rapeseed oil.<h4>Results</h4>Here, we perform a genome-wide association study (GWAS) to identify quantitative trait locus (QTLs) associated with fatty acid content. We identify a total of seven stable QTLs and find two loci, qFA.A08 and qFA.A09.1, subjected to strong selection pressure. By transcriptome-wide association analysis (TWAS), we characterize 3295 genes that are significantly correlated with the composition of at least one fatty acid. To elucidate the genetic underpinnings governing fatty acid composition, we then employ a combination of GWAS, TWAS, and dynamic transcriptomic analysis during seed develop","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-15T11:02:06.37Z","creation":"2026-07-03T03:15:30.426Z"},"accession":"S-EPMC11966889","cross_references":{"pubmed":["40176168"],"doi":["10.1186/s13059-025-03558-x"]}}