{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Song J"],"pubmed_abstract":["Chaetoglobosin A (ChA) is an antitumor compound produced by <i>Chaetomium globosum</i>. However, the mechanism of its antitumor effect has been rarely reported. In this study, we evaluated the anti-proliferative effect of ChA on T-24 human bladder cancer cells and explored its mechanism of action. ChA was found to have a good inhibitory effect on T-24 cells by MTT assay with an IC50 value of 48.14 ± 10.25 μΜ. Moreover, it was found to have a migration inhibitory ability and a sustained proliferation inhibitory effect on tumor cells by cell aggregation assay and cell migration assay. The cells morphological changes were determined by Hoechst33342 assay. While Annexin V-FITC/PI double-staining assay also demonstrated that the number of apoptotic cells increased with the increase of drug conc"],"journal":["PeerJ"],"pagination":["e19085"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11967413"],"repository":["biostudies-literature"],"pubmed_title":["Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway."],"pmcid":["PMC11967413"],"pubmed_authors":["Shi L","Li J","Zheng H","Chen M","Yu D","Qiao J","Wang J","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway.","description":"Chaetoglobosin A (ChA) is an antitumor compound produced by <i>Chaetomium globosum</i>. However, the mechanism of its antitumor effect has been rarely reported. In this study, we evaluated the anti-proliferative effect of ChA on T-24 human bladder cancer cells and explored its mechanism of action. ChA was found to have a good inhibitory effect on T-24 cells by MTT assay with an IC50 value of 48.14 ± 10.25 μΜ. Moreover, it was found to have a migration inhibitory ability and a sustained proliferation inhibitory effect on tumor cells by cell aggregation assay and cell migration assay. The cells morphological changes were determined by Hoechst33342 assay. While Annexin V-FITC/PI double-staining assay also demonstrated that the number of apoptotic cells increased with the increase of drug conc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-11T03:04:08.951Z","creation":"2025-07-11T03:04:08.951Z"},"accession":"S-EPMC11967413","cross_references":{"pubmed":["40183046"],"doi":["10.7717/peerj.19085"]}}