biostudies-literatureUnknown20(4)Sanchez-Pujol J<h4>Objective</h4>Some reports suggest monosodium urate (MSU) crystals may deposit in artery walls. This exploratory study evaluated the capacity of optical coherence tomography (OCT) to detect MSU crystals in vessel phantoms.<h4>Methods</h4>We used 3D-printed blood vessel phantoms made of photosensitive acrylic resins, with varying compliances. 0.1cc volume injections of centrifugated human synovial fluids containing MSU crystals, calcium pyrophosphate crystals or 0.9% saline were performed in four predefined locations in the phantoms. OCT was subsequently performed in a blinded manner by two cardiologists, experts in the technique. Two exploratory definitions for MSU crystal deposits were used, depicting a lesion with high attenuation (#1) or also with a linear morphology (#2). DiagnostiPloS onee0320742https://www.ebi.ac.uk/biostudies/studies/S-EPMC11967950biostudies-literatureCould optical coherence tomography detect monosodium urate crystal deposition at artery walls? An exploratory, phantom-based study.PMC11967950Andres MRuiz-Nodar JMSanchez-Pujol JValencia JfalseCould optical coherence tomography detect monosodium urate crystal deposition at artery walls? An exploratory, phantom-based study.<h4>Objective</h4>Some reports suggest monosodium urate (MSU) crystals may deposit in artery walls. This exploratory study evaluated the capacity of optical coherence tomography (OCT) to detect MSU crystals in vessel phantoms.<h4>Methods</h4>We used 3D-printed blood vessel phantoms made of photosensitive acrylic resins, with varying compliances. 0.1cc volume injections of centrifugated human synovial fluids containing MSU crystals, calcium pyrophosphate crystals or 0.9% saline were performed in four predefined locations in the phantoms. OCT was subsequently performed in a blinded manner by two cardiologists, experts in the technique. Two exploratory definitions for MSU crystal deposits were used, depicting a lesion with high attenuation (#1) or also with a linear morphology (#2). Diagnosti2025-01-01T00:00:00Z20252026-05-29T16:49:37.592Z2025-07-11T03:03:57.783ZS-EPMC119679504017910410.1371/journal.pone.0320742