{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["82"],"submitter":["She G"],"pubmed_abstract":["Cardiomyocyte loss by regulated death modes, like apoptosis and ferroptosis, has been implicated in the development of dilated cardiomyopathy (DCM). It remains unclear whether cardiomyocyte ferroptosis occurs as a consequence of Hippo pathway activation. Using a mouse model of DCM by overexpression of Mst1 transgene (Mst1-TG) leading to Hippo pathway activation, we showed that cardiomyocyte ferroptosis was evident by transcriptomic profiles, elevated mitochondrial Fe<sup>2+</sup> content, increased levels of lipid peroxidation and obvious mitochondrial damage. Transcriptome revealed significant alterations of genes participating in iron metabolism and lipid peroxidation. Treatment of Mst1-TG mice with the ferroptosis inhibitor ferrostatin-1 reduced cardiomyocyte ferroptosis and improved ca"],"journal":["Redox biology"],"pagination":["103597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11968290"],"repository":["biostudies-literature"],"pubmed_title":["Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1."],"pmcid":["PMC11968290"],"pubmed_authors":["Wu LH","Deng XL","Sadoshima J","Zhang YJ","Jia LY","Yang YY","Du XJ","Hai XX","She G","Pang ZD","Zhang Y","Ren YJ","Lai BC","Bai RY","Li JJ","Han MZ"],"additional_accession":[]},"is_claimable":false,"name":"Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1.","description":"Cardiomyocyte loss by regulated death modes, like apoptosis and ferroptosis, has been implicated in the development of dilated cardiomyopathy (DCM). It remains unclear whether cardiomyocyte ferroptosis occurs as a consequence of Hippo pathway activation. Using a mouse model of DCM by overexpression of Mst1 transgene (Mst1-TG) leading to Hippo pathway activation, we showed that cardiomyocyte ferroptosis was evident by transcriptomic profiles, elevated mitochondrial Fe<sup>2+</sup> content, increased levels of lipid peroxidation and obvious mitochondrial damage. Transcriptome revealed significant alterations of genes participating in iron metabolism and lipid peroxidation. Treatment of Mst1-TG mice with the ferroptosis inhibitor ferrostatin-1 reduced cardiomyocyte ferroptosis and improved ca","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T19:19:29.734Z","creation":"2026-04-19T03:13:34.23Z"},"accession":"S-EPMC11968290","cross_references":{"pubmed":["40107016"],"doi":["10.1016/j.redox.2025.103597"]}}