{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Qin XD"],"pubmed_abstract":["<h4>Introduction</h4>Although age is the most important non-modifiable risk factor for cerebral stroke, it is also apparent that females commonly exhibit longer lifespan and better outcome after stroke compared to the age-matched males. A critical event after stroke is the peripheral infiltration of immune cells across damaged blood-brain barrier, which induces inflammatory and immune responses within the brain parenchyma and consequently worsen brain injury. These events are also dependent on age and display a sex different pattern. Theoretically, X chromosome-encoded differential expression genes (DEGs) may explain differences between the sexes. However, the expression and regulation of these DEGs after stroke have not been studied in detail.<h4>Methods</h4>We conducted three datasets of"],"journal":["Frontiers in genetics"],"pagination":["1479270"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11968720"],"repository":["biostudies-literature"],"pubmed_title":["Profiling X chromosome genes expression relevant to sex dimorphism in stroke: insights from transcriptomics landscape analysis."],"pmcid":["PMC11968720"],"pubmed_authors":["Cai Q","Li YR","Dang ZH","Qin XD","Min JW","Bu F","Qi SH","Liu JY","Li LL"],"additional_accession":[]},"is_claimable":false,"name":"Profiling X chromosome genes expression relevant to sex dimorphism in stroke: insights from transcriptomics landscape analysis.","description":"<h4>Introduction</h4>Although age is the most important non-modifiable risk factor for cerebral stroke, it is also apparent that females commonly exhibit longer lifespan and better outcome after stroke compared to the age-matched males. A critical event after stroke is the peripheral infiltration of immune cells across damaged blood-brain barrier, which induces inflammatory and immune responses within the brain parenchyma and consequently worsen brain injury. These events are also dependent on age and display a sex different pattern. Theoretically, X chromosome-encoded differential expression genes (DEGs) may explain differences between the sexes. However, the expression and regulation of these DEGs after stroke have not been studied in detail.<h4>Methods</h4>We conducted three datasets of","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-07-01T03:05:17.988Z","creation":"2025-07-01T03:05:17.988Z"},"accession":"S-EPMC11968720","cross_references":{"pubmed":["40191607"],"doi":["10.3389/fgene.2025.1479270"]}}