biostudies-literatureUnknown15Guo S<h4>Background</h4>Chimeric antigen receptor T cell (CAR-T) therapy for relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgkin lymphoma (B-NHL) patients has shown promising effects, but side effects such as viral infections have been observed.<h4>Methods</h4>A total of 45 patients with r/r B-ALL and r/r B-NHL were included in this retrospective study. Patient demographics were recorded, with the primary endpoint being viral infection within 3 months post CAR-T treatment. Univariate and multivariate logistic regression analyses and least absolute shrinkage and selection operator (LASSO) regression analysis were used to analyze independent factors. The patients were divided into a training cohort of 28 and a validation cohort of 17 to construct a predictFrontiers in oncology1549809https://www.ebi.ac.uk/biostudies/studies/S-EPMC11968754biostudies-literatureA viral infection prediction model for patients with r/r B-cell malignancies after CAR-T therapy: a retrospective analysis.PMC11968754Liu JZhao MCao XWang BZhang XXiao XGuo SZhao YXu JfalseA viral infection prediction model for patients with r/r B-cell malignancies after CAR-T therapy: a retrospective analysis.<h4>Background</h4>Chimeric antigen receptor T cell (CAR-T) therapy for relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgkin lymphoma (B-NHL) patients has shown promising effects, but side effects such as viral infections have been observed.<h4>Methods</h4>A total of 45 patients with r/r B-ALL and r/r B-NHL were included in this retrospective study. Patient demographics were recorded, with the primary endpoint being viral infection within 3 months post CAR-T treatment. Univariate and multivariate logistic regression analyses and least absolute shrinkage and selection operator (LASSO) regression analysis were used to analyze independent factors. The patients were divided into a training cohort of 28 and a validation cohort of 17 to construct a predict2025-01-01T00:00:00Z20252025-07-09T03:05:11.411Z2025-07-09T03:05:11.411ZS-EPMC119687544019055210.3389/fonc.2025.1549809