{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strongin Z"],"funding":["Intramural NIH HHS","Vetenskapsrådet","NIAID NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Institute of Allergy and Infectious Diseases","Vetenskapsrådet (Swedish Research Council)","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","Division of Intramural Research, National Institute of Allergy and Infectious Diseases","Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID)","U.S. Department of Health &amp; Human Services | NIH | National Cancer Institute","NCI NIH HHS","U.S. Department of Health &amp; Human Services | National Institutes of Health","NIH HHS"],"pagination":["1245-1256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11969417"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(7)"],"pubmed_abstract":["Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8<sup>+</sup> T cell functions, which requires a deeper understanding of CD8<sup>+</sup> T cells promoting HIV control. Here we identifiy an antigen-responsive TOX<sup>hi</sup>TCF1<sup>+</sup>CD39<sup>+</sup>CD8<sup>+</sup> T cell population with high expression of inhibitory receptors and low expression of canonical cytolytic molecules. Transcriptional analysis of simian immunodeficiency virus (SIV)-specific CD8<sup>+</sup> T cells and proteomic analysis of purified CD8<sup>+</sup> T cell subsets identified TOX<sup>hi</sup>TCF1<sup>+</sup>CD39<sup>+</sup>CD8<sup>+</sup> T cells as intermediate effectors that retained stem-like features with a lineage relationship with terminal effector T cells. TOX<su"],"journal":["Nature immunology"],"pubmed_title":["Distinct SIV-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence."],"pmcid":["PMC11969417"],"funding_grant_id":["UM1AI164562","R56 AI150401","P51 OD011132","R01AI116379","75N91019D00024","R37 AI141258","ZIA AI001029","2023-00510","P30 AI050409","U42 OD011023","R56AI150401","R01 AI116379","UM1 AI164562","OD026799","1ZIAAI001029","S10 OD026799"],"pubmed_authors":["Raymond Marchand L","Gourves M","Torres-Ruiz F","Luna-Villalobos YA","Paiardini M","Urban EA","Saez-Cirion A","Hoang TN","Deleage C","Harper J","Pampena MB","Kissick HT","Del Rio Estrada PM","Avila-Rios S","Strongin Z","Nguyen K","Beusch CM","Reyes-Teran G","Sekaly R","Rahmberg AR","Gonzalez-Navarro M","Bosinger SE","Tharp GK","Lapp S","Brenchley JM","Kulpa DA","Betts MR","Cardenas MA","Silvestri G","Gordon DE"],"additional_accession":[]},"is_claimable":false,"name":"Distinct SIV-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.","description":"Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8<sup>+</sup> T cell functions, which requires a deeper understanding of CD8<sup>+</sup> T cells promoting HIV control. Here we identifiy an antigen-responsive TOX<sup>hi</sup>TCF1<sup>+</sup>CD39<sup>+</sup>CD8<sup>+</sup> T cell population with high expression of inhibitory receptors and low expression of canonical cytolytic molecules. Transcriptional analysis of simian immunodeficiency virus (SIV)-specific CD8<sup>+</sup> T cells and proteomic analysis of purified CD8<sup>+</sup> T cell subsets identified TOX<sup>hi</sup>TCF1<sup>+</sup>CD39<sup>+</sup>CD8<sup>+</sup> T cells as intermediate effectors that retained stem-like features with a lineage relationship with terminal effector T cells. TOX<su","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T19:19:16.739Z","creation":"2026-04-19T03:13:31.966Z"},"accession":"S-EPMC11969417","cross_references":{"pubmed":["38886592"],"doi":["10.1038/s41590-024-01875-0"]}}