biostudies-literatureJia RScience and Technology Projects of Lianyungang (Social Development)Science and Technology Projects of LianyungangJiangsu Provincial Administration of Traditional Chinese MedicineNational Natural Science Foundation of ChinaPioneer Incubator FundLianyungang Science and Technology Program Project100https://www.ebi.ac.uk/biostudies/studies/S-EPMC11969723biostudies-literatureUnknown22(1)<h4>Background</h4>Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse reaction to chemotherapy with limited treatment options. Research has indicated that neutrophil extracellular traps (NETs) are critical for the pathogenesis of CIPN. LPS/HMGB1 serve as important inducers of NETs. Here, we aimed to target the inhibition of NET formation (NETosis) to alleviate CIPN.<h4>Methods</h4>Oxaliplatin (L-OHP) was used to establish a CIPN model. The mice were pretreated with fucoidan to investigate the therapeutic effect. SR-A1^-/- mice were used to examine the role of scavenger receptor A1 (SR-A1) in CIPN. Bone marrow-derived macrophages (BMDMs) isolated from SR-A1^-/- mice and WT mice were used to investigate the mechanism by which macrophage phagocytosis ofJournal of neuroinflammationFucoidan reduces NET accumulation and alleviates chemotherapy-induced peripheral neuropathy via the gut-blood-DRG axis.PMC11969723SF2314MS202312282271252SF212282073910GWRX-BR-2024-382204542Wan LLiu WTZhang MZhang YJia RMiao CZong LCai YChen YZhu XMa JHu LJin LTian QWu XfalseFucoidan reduces NET accumulation and alleviates chemotherapy-induced peripheral neuropathy via the gut-blood-DRG axis.<h4>Background</h4>Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse reaction to chemotherapy with limited treatment options. Research has indicated that neutrophil extracellular traps (NETs) are critical for the pathogenesis of CIPN. LPS/HMGB1 serve as important inducers of NETs. Here, we aimed to target the inhibition of NET formation (NETosis) to alleviate CIPN.<h4>Methods</h4>Oxaliplatin (L-OHP) was used to establish a CIPN model. The mice were pretreated with fucoidan to investigate the therapeutic effect. SR-A1^-/- mice were used to examine the role of scavenger receptor A1 (SR-A1) in CIPN. Bone marrow-derived macrophages (BMDMs) isolated from SR-A1^-/- mice and WT mice were used to investigate the mechanism by which macrophage phagocytosis of2025-01-01T00:00:00Z2025 Apr2026-06-02T17:32:58.328Z2025-07-08T03:13:08.382ZS-EPMC119697234018624510.1186/s12974-025-03431-5