{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Doar E"],"funding":["Fungi Perfecti, LLC"],"pubmed_abstract":["<h4>Background</h4>Lion's mane (Hericium erinaceus) mycelium produces erinacines, a suite of cyathane diterpenoids with established neuroactivities. While H. erinaceus fruit body tissue has its own characteristic secondary metabolites, it generally does not produce detectable amounts of erinacines. Substrate composition influences the erinacine content of H. erinaceus mycelial cultures, similar to production of secondary metabolites in other fungi. This study explored the relationship between biosynthetic gene expression and erinacine content in H. erinaceus, comparing fruit body tissue to mycelial tissue cultured in two liquid media formulations.<h4>Results</h4>In this study, we compared erinacine production in H. erinaceus fruit body to mycelial tissue cultivated in two liquid media form"],"journal":["Fungal biology and biotechnology"],"pagination":["4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11969743"],"repository":["biostudies-literature"],"pubmed_title":["Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus."],"pmcid":["PMC11969743"],"pubmed_authors":["Doar E","Meyer KW","McNalley S","Bair ZJ","Nally R","Davis R","Beathard C"],"additional_accession":[]},"is_claimable":false,"name":"Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus.","description":"<h4>Background</h4>Lion's mane (Hericium erinaceus) mycelium produces erinacines, a suite of cyathane diterpenoids with established neuroactivities. While H. erinaceus fruit body tissue has its own characteristic secondary metabolites, it generally does not produce detectable amounts of erinacines. Substrate composition influences the erinacine content of H. erinaceus mycelial cultures, similar to production of secondary metabolites in other fungi. This study explored the relationship between biosynthetic gene expression and erinacine content in H. erinaceus, comparing fruit body tissue to mycelial tissue cultured in two liquid media formulations.<h4>Results</h4>In this study, we compared erinacine production in H. erinaceus fruit body to mycelial tissue cultivated in two liquid media form","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T23:15:53.473Z","creation":"2025-07-01T03:05:22.575Z"},"accession":"S-EPMC11969743","cross_references":{"pubmed":["40181478"],"doi":["10.1186/s40694-025-00194-9"]}}