{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(14)"],"submitter":["Huynh QT"],"pubmed_abstract":["<i>Elatostema tenuicaudatum</i> W. T. Wang, a medicinal plant traditionally utilized in herbal remedies, was explored for its cytotoxic properties. Bioassay-guided fractionation led to the discovery of six novel compounds, designated as elatostemanosides I-VI, with their structures elucidated through advanced spectroscopic methods and DP4+ analysis. Among these, compounds 2, 5, and 6 demonstrated moderate cytotoxicity against the human liver cancer cell line HepG2, exhibiting IC<sub>50</sub> values of 18.2 ± 2.1, 32.1 ± 0.4, and 57.6 ± 1.3 µM, respectively. Notably, compound 6 also displayed significant activity against the human breast cancer cell line HCC1806, with an IC<sub>50</sub> value of 35.4 ± 0.3 µM. Mechanistic studies revealed these compounds induced apoptosis by modulating the "],"journal":["RSC advances"],"pagination":["10639-10652"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11970508"],"repository":["biostudies-literature"],"pubmed_title":["Cytotoxicity-guided isolation of elatostemanosides I-VI from &lt;i&gt;Elatostema tenuicaudatum&lt;/i&gt; W. T. Wang and their cytotoxic activities."],"pmcid":["PMC11970508"],"pubmed_authors":["Fan YJ","Kuo CC","Liu TW","Phan TT","Chu MH","Nguyen DK","Hsu SJ","Wang YH","Lee CK","Nguyen TV","Shen YA","Vo TH","Huynh QT","Duong TT"],"additional_accession":[]},"is_claimable":false,"name":"Cytotoxicity-guided isolation of elatostemanosides I-VI from &lt;i&gt;Elatostema tenuicaudatum&lt;/i&gt; W. T. Wang and their cytotoxic activities.","description":"<i>Elatostema tenuicaudatum</i> W. T. Wang, a medicinal plant traditionally utilized in herbal remedies, was explored for its cytotoxic properties. Bioassay-guided fractionation led to the discovery of six novel compounds, designated as elatostemanosides I-VI, with their structures elucidated through advanced spectroscopic methods and DP4+ analysis. Among these, compounds 2, 5, and 6 demonstrated moderate cytotoxicity against the human liver cancer cell line HepG2, exhibiting IC<sub>50</sub> values of 18.2 ± 2.1, 32.1 ± 0.4, and 57.6 ± 1.3 µM, respectively. Notably, compound 6 also displayed significant activity against the human breast cancer cell line HCC1806, with an IC<sub>50</sub> value of 35.4 ± 0.3 µM. Mechanistic studies revealed these compounds induced apoptosis by modulating the ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-09T03:05:11.283Z","creation":"2025-07-09T03:05:11.283Z"},"accession":"S-EPMC11970508","cross_references":{"pubmed":["40190632"],"doi":["10.1039/d4ra09007a"]}}