biostudies-literatureLi XNIBIB NIH HHSNINDS NIH HHSNCI NIH HHSNational Institutes of HealthNIH HHSthe Center for Magnetic Resonance Research (CMRR), University of Minnesota2640-2654https://www.ebi.ac.uk/biostudies/studies/S-EPMC11971487biostudies-literatureUnknown93(6)<h4>Purpose</h4>Phosphorus-31 (<sup>31</sup>P) MR spectroscopy imaging (MRSI) at 7 T is a powerful tool for investigating high-energy phosphate metabolism in human brains with significantly improved signal-to-noise ratio (SNR) and spectral resolution. However, this imaging technique requires dual-frequency radiofrequency coil for performing brain anatomical imaging and B<sub>0</sub> shimming at proton (<sup>1</sup>H) operation frequency, and <sup>31</sup>P MRSI at lower operation frequency. Herein, we introduce a novel <sup>31</sup>P-<sup>1</sup>H dual-frequency radiofrequency coil design using a double-tuned and double-matched (DODO) coil that does not require complex circuitry or two coil layers and exhibits similar imaging performance as to single-frequency control coils for both <sup>3Magnetic resonance in medicineA novel multifrequency-tuned transceiver array for human-brain <sup>31</sup>P-MRSI at 7 T.PMC11971487R01CA240953P41 EB027061U01 EB026978R01NS133006R01 CA240953R01 NS133006Li XWaks MChen WZhu XHZhang XLfalseA novel multifrequency-tuned transceiver array for human-brain <sup>31</sup>P-MRSI at 7 T.<h4>Purpose</h4>Phosphorus-31 (<sup>31</sup>P) MR spectroscopy imaging (MRSI) at 7 T is a powerful tool for investigating high-energy phosphate metabolism in human brains with significantly improved signal-to-noise ratio (SNR) and spectral resolution. However, this imaging technique requires dual-frequency radiofrequency coil for performing brain anatomical imaging and B<sub>0</sub> shimming at proton (<sup>1</sup>H) operation frequency, and <sup>31</sup>P MRSI at lower operation frequency. Herein, we introduce a novel <sup>31</sup>P-<sup>1</sup>H dual-frequency radiofrequency coil design using a double-tuned and double-matched (DODO) coil that does not require complex circuitry or two coil layers and exhibits similar imaging performance as to single-frequency control coils for both <sup>32025-01-01T00:00:00Z2025 Jun2025-07-08T03:13:53.501Z2025-07-08T03:13:53.501ZS-EPMC119714873990251710.1002/mrm.30449