{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Belsley G"],"funding":["NIHR Oxford Biomedical Research Centre","Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (MRC)"],"pagination":["2331-2345"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11971508"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["93(6)"],"pubmed_abstract":["<h4>Purpose</h4>To develop an accurate and precise liver 3D T1$$ {T}_1 $$ mapping method using only scanner-agnostic sequences.<h4>Methods</h4>While the spoiled gradient-recalled echo sequence is widely available on clinical scanners, variable flip angle T1$$ {T}_1 $$ mapping methods based on this sequence provide biased T1$$ {T}_1 $$ estimates, with the largest systematic error arising from B1+$$ {B}_1^{+} $$ inhomogeneities. To correct for this, the flip angle was mapped using a 2D gradient-echo double-angle method approach. To correct for the confounding effect of fat on liver T1$$ {T}_1 $$ and B1+$$ {B}_1^{+} $$ , Dixon and fat saturation techniques were used in combination with the variable flip angle and the B1+$$ {B}_1^{+} $$ map acquisitions, respectively. The T1$$ {T}_1 $$ and B1+"],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Accurate and precise in vivo liver 3D T&lt;sub&gt;1&lt;/sub&gt; mapping at 3T."],"pmcid":["PMC11971508"],"funding_grant_id":["EP/L016052/1"],"pubmed_authors":["Tyler DJ","Tunnicliffe EM","Belsley G","Robson MD","Mozes FE"],"additional_accession":[]},"is_claimable":false,"name":"Accurate and precise in vivo liver 3D T&lt;sub&gt;1&lt;/sub&gt; mapping at 3T.","description":"<h4>Purpose</h4>To develop an accurate and precise liver 3D T1$$ {T}_1 $$ mapping method using only scanner-agnostic sequences.<h4>Methods</h4>While the spoiled gradient-recalled echo sequence is widely available on clinical scanners, variable flip angle T1$$ {T}_1 $$ mapping methods based on this sequence provide biased T1$$ {T}_1 $$ estimates, with the largest systematic error arising from B1+$$ {B}_1^{+} $$ inhomogeneities. To correct for this, the flip angle was mapped using a 2D gradient-echo double-angle method approach. To correct for the confounding effect of fat on liver T1$$ {T}_1 $$ and B1+$$ {B}_1^{+} $$ , Dixon and fat saturation techniques were used in combination with the variable flip angle and the B1+$$ {B}_1^{+} $$ map acquisitions, respectively. The T1$$ {T}_1 $$ and B1+","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2025-07-08T03:13:38.555Z","creation":"2025-07-08T03:13:38.555Z"},"accession":"S-EPMC11971508","cross_references":{"pubmed":["39902594"],"doi":["10.1002/mrm.30448"]}}