{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["105"],"submitter":["Wang CY"],"pubmed_abstract":["Basal cell nevus syndrome is caused by mutations in the Sonic hedgehog pathway and characterized by early-onset basal cell carcinoma. The features of basal cell carcinoma in basal cell nevus syndrome compared with sporadic basal cell carcinoma have not been explored. This study is a retrospective study of patients with basal cell nevus syndrome in two medical centres in Taiwan from 1991 to 2021 and patients with sporadic basal cell carcinoma excised from 2015 to 2020. An analysis of 18 patients with basal cell nevus syndrome showed an older mean age at the first diagnosis of basal cell carcinoma (37.5 years) than reported in Western countries. The majority of basal cell carcinomas were located in the head and neck region (80.7%), with nodular BCC being the most common tumour type (47.0%). "],"journal":["Acta dermato-venereologica"],"pagination":["adv40692"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11971840"],"repository":["biostudies-literature"],"pubmed_title":["Basal Cell Nevus Syndrome and Sporadic Basal Cell Carcinoma: A Comparative Study of Clinicopathological Features."],"pmcid":["PMC11971840"],"pubmed_authors":["Lu LY","Chen JS","Sheen YS","Chen CB","Liau JY","Sung WY","Hong JB","Chang YY","Wang CY","Ilagan FMD","Lin JY","Liao YH","Chen YH"],"additional_accession":[]},"is_claimable":false,"name":"Basal Cell Nevus Syndrome and Sporadic Basal Cell Carcinoma: A Comparative Study of Clinicopathological Features.","description":"Basal cell nevus syndrome is caused by mutations in the Sonic hedgehog pathway and characterized by early-onset basal cell carcinoma. The features of basal cell carcinoma in basal cell nevus syndrome compared with sporadic basal cell carcinoma have not been explored. This study is a retrospective study of patients with basal cell nevus syndrome in two medical centres in Taiwan from 1991 to 2021 and patients with sporadic basal cell carcinoma excised from 2015 to 2020. An analysis of 18 patients with basal cell nevus syndrome showed an older mean age at the first diagnosis of basal cell carcinoma (37.5 years) than reported in Western countries. The majority of basal cell carcinomas were located in the head and neck region (80.7%), with nodular BCC being the most common tumour type (47.0%). ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-08T03:12:47.798Z","creation":"2025-07-08T03:12:47.798Z"},"accession":"S-EPMC11971840","cross_references":{"pubmed":["40105068"],"doi":["10.2340/actadv.v105.40692"]}}