biostudies-literatureCorvino AGrand Équipement National de Calcul IntensifEuropean Research CouncilEuropean High Performance Computing Joint Undertaking2493-2506https://www.ebi.ac.uk/biostudies/studies/S-EPMC11972043biostudies-literatureUnknown52(4)<h4>Background</h4>Breast cancer is the leading cause of female cancer mortality worldwide, accounting for 1 in 6 cancer deaths. Surgery, radiation, and systemic therapy are the three pillars of breast cancer treatment, with several strategies developed to combine them. The association of preoperative radiotherapy with immunotherapy may improve breast cancer tumor control by exploiting the tumor radio-induced immune priming. However, this requires the use of hypofractionated radiotherapy (3 × 8 Gy), increasing the risk of toxicity. Mini-GRID therapy (mini-GRT) is an innovative form of spatially fractionated radiation therapy (SFRT) characterized by narrow beam widths between 1 to 2 mm that promises a significant increase in normal tissue dose tolerances and could thereby represent a new alMedical physicsPhoton mini-GRID therapy for preoperative breast cancer tumor treatment: A treatment plan study.PMC11972043EHPC‐REG‐2022R02‐177817908EHPC-REG-2022R02-177A0150314559A0130313736Corvino ASchneider TLoap PVu-Bezin JKirova YPrezado YfalsePhoton mini-GRID therapy for preoperative breast cancer tumor treatment: A treatment plan study.<h4>Background</h4>Breast cancer is the leading cause of female cancer mortality worldwide, accounting for 1 in 6 cancer deaths. Surgery, radiation, and systemic therapy are the three pillars of breast cancer treatment, with several strategies developed to combine them. The association of preoperative radiotherapy with immunotherapy may improve breast cancer tumor control by exploiting the tumor radio-induced immune priming. However, this requires the use of hypofractionated radiotherapy (3 × 8 Gy), increasing the risk of toxicity. Mini-GRID therapy (mini-GRT) is an innovative form of spatially fractionated radiation therapy (SFRT) characterized by narrow beam widths between 1 to 2 mm that promises a significant increase in normal tissue dose tolerances and could thereby represent a new al2025-01-01T00:00:00Z2025 Apr2025-07-08T03:12:50.2Z2025-07-08T03:12:50.2ZS-EPMC119720433987391010.1002/mp.17634