{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tierney KI"],"funding":["Western Michigan University"],"pagination":["e70797"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11973136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(7)"],"pubmed_abstract":["<h4>Introduction</h4>Infertility is a concerning late effect of cancer and cancer treatments, yet referrals for fertility preservation are unequal across U.S. sociodemographic groups. Although all-site cancer incidence varies across U.S. sociodemographic groups, it is unclear whether fertility-impacting cancers, specifically, are unevenly distributed by sex or race/ethnicity.<h4>Methods</h4>Cross-sectional analysis of cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program (2010-2020). Age-specific demographic rates and negative binomial regression with an exposure for population size were employed to assess inequalities in the incidence rates of fertility-impacting cancers among U.S. individuals aged 39 and younger. Wald tests were used to compare coefficients across the multivariable negative binomial regression models.<h4>Results</h4>Women had higher incidence rates of fertility-impacting cancers (cancers of the reproductive organs, cancers in areas proximal to the reproductive organs or that contribute to reproductive functioning, and other cancers identified in the literature as fertility-impacting) in the fully adjusted models. These associations differed from the patterns observed among all other types of cancers. The incidence rates of fertility-impacting cancers also varied by race/ethnic groups. However, the patterning observed by race-ethnicity varied between the three fertility-impacting cancer groups.<h4>Conclusion</h4>The burden of fertility-impacting cancers is unequal across sex and race/ethnic groups. The sociodemographic patterns observed in fertility-impacting cancers differ substantively from cancers that were not identified as fertility-impacting. The findings reinforce the importance of screening for fertility-impacting cancers and identify a potential unmet need for both fertility preservation referrals among cancer patients and access to fertility treatment for survivors of cancer."],"journal":["Cancer medicine"],"pubmed_title":["Inequalities in Fertility-Impacting Cancer Incidence Among Young Populations in the United States."],"pmcid":["PMC11973136"],"funding_grant_id":["FRACAA #002627"],"pubmed_authors":["Graves L","Ellwood S","Therrien J","Tierney KI"],"additional_accession":[]},"is_claimable":false,"name":"Inequalities in Fertility-Impacting Cancer Incidence Among Young Populations in the United States.","description":"<h4>Introduction</h4>Infertility is a concerning late effect of cancer and cancer treatments, yet referrals for fertility preservation are unequal across U.S. sociodemographic groups. Although all-site cancer incidence varies across U.S. sociodemographic groups, it is unclear whether fertility-impacting cancers, specifically, are unevenly distributed by sex or race/ethnicity.<h4>Methods</h4>Cross-sectional analysis of cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program (2010-2020). Age-specific demographic rates and negative binomial regression with an exposure for population size were employed to assess inequalities in the incidence rates of fertility-impacting cancers among U.S. individuals aged 39 and younger. Wald tests were used to compare coefficients across the multivariable negative binomial regression models.<h4>Results</h4>Women had higher incidence rates of fertility-impacting cancers (cancers of the reproductive organs, cancers in areas proximal to the reproductive organs or that contribute to reproductive functioning, and other cancers identified in the literature as fertility-impacting) in the fully adjusted models. These associations differed from the patterns observed among all other types of cancers. The incidence rates of fertility-impacting cancers also varied by race/ethnic groups. However, the patterning observed by race-ethnicity varied between the three fertility-impacting cancer groups.<h4>Conclusion</h4>The burden of fertility-impacting cancers is unequal across sex and race/ethnic groups. The sociodemographic patterns observed in fertility-impacting cancers differ substantively from cancers that were not identified as fertility-impacting. The findings reinforce the importance of screening for fertility-impacting cancers and identify a potential unmet need for both fertility preservation referrals among cancer patients and access to fertility treatment for survivors of cancer.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-13T03:06:06.826Z","creation":"2025-07-13T03:06:06.826Z"},"accession":"S-EPMC11973136","cross_references":{"pubmed":["40189850"],"doi":["10.1002/cam4.70797"]}}