biostudies-literatureUnknown281(5)Neal MD<h4>Objective</h4>To determine the feasibility, efficacy, and safety of cold storage compared with room temperature (RT) platelet transfusion in patients with traumatic brain injury (TBI).<h4>Background</h4>Data demonstrating the safety and efficacy of cold-stored platelet (CSP) transfusion are lacking after TBI.<h4>Methods</h4>A phase 2, randomized, open-label clinical trial was performed at a single U.S. trauma center. Traumatic brain-injured patients with positive brain imaging and a need for platelet transfusion received up to 2 apheresis units of CSPs stored out to 14 days versus standard care RT platelet transfusion. The primary outcome was feasibility and the principal clinical outcome for efficacy and safety was the 6-month Glasgow Coma Scale-extended score.<h4>Results</h4>The 6-moAnnals of surgery796-805https://www.ebi.ac.uk/biostudies/studies/S-EPMC11974628biostudies-literatureEarly Cold-stored Platelet Transfusion following Traumatic Brain Injury: A Randomized Clinical Trial.PMC11974628Agnone AGMerti AHahner TOkonkwo DOPattison Aand the Cold Stored Platelet for Traumatic Brain Injury (CRISP-TBI) study groupSpinella PCLove ETRaymond OWisniewski SRGimbel ERogers NFilicky ALuther JFHarner AMOver LSperry JLWeinman DRBrubaker DPSilfies LMcIntyre PPanthalukaran TPeet CLeeper CMAgostino LCorrell AMacey-Kalcevic MEarly-Young BYazer MHGuyette FXVincent LEForsythe RBuck MNeal MDPuccio AMBrown JBfalseEarly Cold-stored Platelet Transfusion following Traumatic Brain Injury: A Randomized Clinical Trial.<h4>Objective</h4>To determine the feasibility, efficacy, and safety of cold storage compared with room temperature (RT) platelet transfusion in patients with traumatic brain injury (TBI).<h4>Background</h4>Data demonstrating the safety and efficacy of cold-stored platelet (CSP) transfusion are lacking after TBI.<h4>Methods</h4>A phase 2, randomized, open-label clinical trial was performed at a single U.S. trauma center. Traumatic brain-injured patients with positive brain imaging and a need for platelet transfusion received up to 2 apheresis units of CSPs stored out to 14 days versus standard care RT platelet transfusion. The primary outcome was feasibility and the principal clinical outcome for efficacy and safety was the 6-month Glasgow Coma Scale-extended score.<h4>Results</h4>The 6-mo2025-01-01T00:00:00Z2025 May2026-06-06T23:30:02.19Z2026-06-06T03:11:19.607ZS-EPMC119746283984043810.1097/SLA.0000000000006640