{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Gadad SS"],"funding":["NCI NIH HHS","NIGMS NIH HHS","NIH HHS"],"pubmed_abstract":["Recent studies have demonstrated that a subset of long \"noncoding\" RNAs (lncRNAs) produce functional polypeptides and proteins. In this study, we discovered a 132 amino acid protein in human breast cancer cells named XCP (X-linked Cancer-associated Polypeptide), which is encoded by <i>lncRNA1456</i> (a.k.a. <i>RHOXF1P3</i>), a transcript previously thought to be noncoding. <i>lncRNA1456</i> is a pancreas- and testis-specific RNA whose gene is located on chromosome X. We found that the expression of <i>lncRNA1456</i> and XCP are highly upregulated in the luminal A, luminal B, and HER2 molecular subtypes of breast cancer. XCP modulates both estrogen-dependent and estrogen-independent growth of breast cancer cells by regulating cancer pathways, as shown in cell and xenograft models. XCP shares some homology with homeodomain-containing proteins and interacts with the histone demethylase plant homeodomain finger protein 8 (PHF8), which is also encoded by an X-linked gene. Mechanistically, XCP stimulates the histone demethylase activity of PHF8 to regulate gene expression in breast cancer cells. These findings identify XCP as a coregulator of transcription and emphasize the need to interrogate the potential functional roles of open reading frames originating from noncoding RNAs."],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.03.21.644649"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11974697"],"repository":["biostudies-literature"],"pubmed_title":["X-Linked Cancer-Associated Polypeptide (XCP) from &lt;i&gt;lncRNA1456&lt;/i&gt; Cooperates with PHF8 to Regulate Gene Expression and Cellular Pathways in Breast Cancer."],"pmcid":["PMC11974697"],"funding_grant_id":["S10 OD021684","R16 GM149497","P30 CA142543"],"pubmed_authors":["Koul S","Peng Y","Nagari A","Thornton M","Camacho CV","Malladi VS","Kraus WL","Sundaresan A","Nandu T","Gadad SS","Gong X"],"additional_accession":[]},"is_claimable":false,"name":"X-Linked Cancer-Associated Polypeptide (XCP) from &lt;i&gt;lncRNA1456&lt;/i&gt; Cooperates with PHF8 to Regulate Gene Expression and Cellular Pathways in Breast Cancer.","description":"Recent studies have demonstrated that a subset of long \"noncoding\" RNAs (lncRNAs) produce functional polypeptides and proteins. In this study, we discovered a 132 amino acid protein in human breast cancer cells named XCP (X-linked Cancer-associated Polypeptide), which is encoded by <i>lncRNA1456</i> (a.k.a. <i>RHOXF1P3</i>), a transcript previously thought to be noncoding. <i>lncRNA1456</i> is a pancreas- and testis-specific RNA whose gene is located on chromosome X. We found that the expression of <i>lncRNA1456</i> and XCP are highly upregulated in the luminal A, luminal B, and HER2 molecular subtypes of breast cancer. XCP modulates both estrogen-dependent and estrogen-independent growth of breast cancer cells by regulating cancer pathways, as shown in cell and xenograft models. XCP shares some homology with homeodomain-containing proteins and interacts with the histone demethylase plant homeodomain finger protein 8 (PHF8), which is also encoded by an X-linked gene. Mechanistically, XCP stimulates the histone demethylase activity of PHF8 to regulate gene expression in breast cancer cells. These findings identify XCP as a coregulator of transcription and emphasize the need to interrogate the potential functional roles of open reading frames originating from noncoding RNAs.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-08T19:27:39.155Z","creation":"2026-04-08T13:31:15.959Z"},"accession":"S-EPMC11974697","cross_references":{"pubmed":["40196671"],"doi":["10.1101/2025.03.21.644649"]}}