biostudies-literatureUnknownZhang BNCATS NIH HHSNHLBI NIH HHS<h4>Importance</h4>Post-acute sequelae of SARS-CoV-2 infection (PASC) remains a major public health challenge. While previous studies have focused on characterizing PASC and identifying its subphenotypes in children and adolescents following an initial SARS-CoV-2 infection, the risks of PASC with Omicron-variant reinfections remain unclear. Using a real-world data approach, this study investigates the risks of PASC following reinfections during the Omicron phase in the pediatric population.<h4>Objective</h4>To investigate the risks of PASC diagnosis and 24 PASC symptoms and conditions after reinfection of SARS-CoV-2 during Omicron period in the pediatric population.<h4>Design setting and participants</h4>This retrospective cohort study used data from the RECOVER consortium comprising 40 chmedRxiv : the preprint server for health sciences2025.03.28.25324858https://www.ebi.ac.uk/biostudies/studies/S-EPMC11974971biostudies-literatureReinfection with SARS-CoV-2 in the Omicron Era is Associated with Increased Risk of Post-Acute Sequelae of SARS-CoV-2 Infection: A RECOVER-EHR Cohort Study.PMC11974971OT2 HL161847UL1 TR001878Horowitz CRJhaveri RChuang CHLiebovitz DMBisyuk YLiu MWu QTaylor BWZhou TFort DCowell LGKim SWilliams DAForrest CBSuresh SSchwenk HTChrischilles EAMosa ASMChen YBecich MJLadino NZhang BBlancero FMorris JSfalseReinfection with SARS-CoV-2 in the Omicron Era is Associated with Increased Risk of Post-Acute Sequelae of SARS-CoV-2 Infection: A RECOVER-EHR Cohort Study.<h4>Importance</h4>Post-acute sequelae of SARS-CoV-2 infection (PASC) remains a major public health challenge. While previous studies have focused on characterizing PASC and identifying its subphenotypes in children and adolescents following an initial SARS-CoV-2 infection, the risks of PASC with Omicron-variant reinfections remain unclear. Using a real-world data approach, this study investigates the risks of PASC following reinfections during the Omicron phase in the pediatric population.<h4>Objective</h4>To investigate the risks of PASC diagnosis and 24 PASC symptoms and conditions after reinfection of SARS-CoV-2 during Omicron period in the pediatric population.<h4>Design setting and participants</h4>This retrospective cohort study used data from the RECOVER consortium comprising 40 ch2025-01-01T00:00:00Z2025 Mar2026-06-06T03:24:39.729Z2025-07-06T03:04:15.566ZS-EPMC119749714019628510.1101/2025.03.28.25324858