{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Mukhija S"],"funding":["NIA NIH HHS","NIDCD NIH HHS"],"pubmed_abstract":["<h4>Importance</h4>Severe COVID-19 infection has been associated with neurological complications, but its role in accelerating cognitive decline remains unclear.<h4>Objective</h4>To determine whether individuals hospitalized for severe COVID-19 exhibit a higher incidence of new onset cognitive impairment compared to those hospitalized for other conditions.<h4>Design</h4>A retrospective study emulating a target trial using Mass General Brigham electronic health records (March 2020-August 2024). The causal effect of COVID-19 hospitalization was estimated via cumulative incidence functions accounting for the competing risk of death.<h4>Setting</h4>Multicenter hospital-based study across the Mass General Brigham healthcare system.<h4>Participants</h4>A total of 221613 hospitalized patients met"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.03.26.25324688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11974976"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Severe COVID-19 on Accelerating Dementia Onset: Clinical and Epidemiological Insights."],"pmcid":["PMC11974976"],"funding_grant_id":["R01 AG058063","U01 DC019579"],"pubmed_authors":["Magdamo C","Mukhija S","Albers MW","Sunog M"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Severe COVID-19 on Accelerating Dementia Onset: Clinical and Epidemiological Insights.","description":"<h4>Importance</h4>Severe COVID-19 infection has been associated with neurological complications, but its role in accelerating cognitive decline remains unclear.<h4>Objective</h4>To determine whether individuals hospitalized for severe COVID-19 exhibit a higher incidence of new onset cognitive impairment compared to those hospitalized for other conditions.<h4>Design</h4>A retrospective study emulating a target trial using Mass General Brigham electronic health records (March 2020-August 2024). The causal effect of COVID-19 hospitalization was estimated via cumulative incidence functions accounting for the competing risk of death.<h4>Setting</h4>Multicenter hospital-based study across the Mass General Brigham healthcare system.<h4>Participants</h4>A total of 221613 hospitalized patients met","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-10T03:08:16.076Z","creation":"2025-07-10T03:08:16.076Z"},"accession":"S-EPMC11974976","cross_references":{"pubmed":["40196257"],"doi":["10.1101/2025.03.26.25324688"]}}