biostudies-literatureUnknown50(2)Nagao Y<h4>Background</h4>Alterations in DNA, such as DNA methylation, may be key molecular events involved in the development of major depressive disorder (MDD). We sought to clarify correlations between DNA methylation profiles and symptom heterogeneity among patients with MDD.<h4>Methods</h4>We conducted a genome-wide DNA methylation analysis of blood samples from patients with MDD and controls, using the Infinium MethylationEPIC BeadChip.<h4>Results</h4>We analyzed 283 blood samples, including 141 from an initial cohort (69 patients with MDD, 72 controls) and 142 from a second validation cohort (67 patients with MDD, 75 controls). After adjustment for age, sex, and blood cell heterogeneity, DNA methylation status at 2699 CpG sites tended to differ between patients with MDD and controls in botJournal of psychiatry & neuroscience : JPNE112-E124https://www.ebi.ac.uk/biostudies/studies/S-EPMC11975397biostudies-literatureGenome-wide DNA methylation profiling of blood samples from patients with major depressive disorder: correlation with symptom heterogeneity.PMC11975397Fujimoto MArai EKameyama STian YHidese SKunugi HKanai YNagao YHattori KfalseGenome-wide DNA methylation profiling of blood samples from patients with major depressive disorder: correlation with symptom heterogeneity.<h4>Background</h4>Alterations in DNA, such as DNA methylation, may be key molecular events involved in the development of major depressive disorder (MDD). We sought to clarify correlations between DNA methylation profiles and symptom heterogeneity among patients with MDD.<h4>Methods</h4>We conducted a genome-wide DNA methylation analysis of blood samples from patients with MDD and controls, using the Infinium MethylationEPIC BeadChip.<h4>Results</h4>We analyzed 283 blood samples, including 141 from an initial cohort (69 patients with MDD, 72 controls) and 142 from a second validation cohort (67 patients with MDD, 75 controls). After adjustment for age, sex, and blood cell heterogeneity, DNA methylation status at 2699 CpG sites tended to differ between patients with MDD and controls in bot2025-01-01T00:00:00Z2025 Mar-Apr2026-06-03T04:53:41.804Z2026-05-28T03:05:55.032ZS-EPMC119753974017493010.1503/jpn.240126