{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Swamynathan MM"],"funding":["NCI NIH HHS"],"pagination":["eadk9167"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11975464"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["386(6720)"],"pubmed_abstract":["Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K precursor [menadione sodium bisulfite (MSB)] suppresses PC progression in mice, killing cells through an oxidative cell death: MSB antagonizes the essential class III phosphatidylinositol (PI) 3-kinase VPS34-the regulator of endosome identity and sorting-through oxidation of key cysteines, pointing to a redox checkpoint in sorting. Testing MSB in a myotubular myopathy model that is driven by loss of <i>MTM1</i>-the phosphatase antagonist of VPS34-we show that dietary MSB improved muscle histology and function and extended life span. These findings enhance our understanding of pro-oxidant sel"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function."],"pmcid":["PMC11975464"],"funding_grant_id":["R01 CA193256","P30 CA045508","R01 CA275128","R01 CA188134","R01 CA190092","U01 CA210240","R01 CA229699","R01 CA137050","U01 CA224013"],"pubmed_authors":["Liu J","Minicozzi F","Spokaite S","Chakrabarty RP","Hicks JB","Chandel NS","Swamynathan MM","Kim ST","Egeblad M","Wilkinson JE","Gineste C","Nowak DG","Zhao X","Rivera K","Tuveson DA","Trotman LC","Mathew G","Park Y","Diermeier SD","Cifani P","Almeida AS","Dessus AN","Alsudani H","Cheng E","Ghosh D","Chang K","Kendall J","Reczek CR","Kuang S","Gong GQ","Janowitz T","Wigler M","Reiss D","Gimotty PA","Watrud KE","Cox H","Wee TL","Herzka T","Williams RL","Doherty MR","Pappin DJ","Klingbeil O","Vakoc CR","Laporte J","Locasale JW"],"additional_accession":[]},"is_claimable":false,"name":"Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function.","description":"Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K precursor [menadione sodium bisulfite (MSB)] suppresses PC progression in mice, killing cells through an oxidative cell death: MSB antagonizes the essential class III phosphatidylinositol (PI) 3-kinase VPS34-the regulator of endosome identity and sorting-through oxidation of key cysteines, pointing to a redox checkpoint in sorting. Testing MSB in a myotubular myopathy model that is driven by loss of <i>MTM1</i>-the phosphatase antagonist of VPS34-we show that dietary MSB improved muscle histology and function and extended life span. These findings enhance our understanding of pro-oxidant sel","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-02T04:17:38.136Z","creation":"2025-07-05T03:04:47.268Z"},"accession":"S-EPMC11975464","cross_references":{"pubmed":["39446948"],"doi":["10.1126/science.adk9167"]}}