{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang TJ"],"funding":["Natural Science Foundation of Jiangxi Province","Health Commission of Jiangxi Province"],"pagination":["142"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11977089"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["82(1)"],"pubmed_abstract":["<h4>Background</h4>Sarcopenia, the age-related decline in muscle mass and function, poses a major health risk to the elderly population. Although dietary advanced glycation end-products (AGEs) have been implicated in worsening sarcopenia, the precise molecular mechanisms remain unclear.<h4>Methods</h4>A sarcopenia animal model was established by feeding a high AGE diet to C57BL/6 mice. Muscle function and mass were assessed using grip strength tests, and rotarod tests. Proteomic analysis was used to identify differentially expressed proteins. Immunoprecipitation, mass spectrometry, and co-immunoprecipitation were employed to investigate protein interactions both in vivo and in vitro. Quantitative reverse transcription PCR and Western blotting were conducted to measure gene and protein expr"],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation."],"pmcid":["PMC11977089"],"funding_grant_id":["20242BAB25539","202310009"],"pubmed_authors":["Wan Q","Huang TJ","Li Q","Li YJ","Zheng JN","Shang S","Chen FX"],"additional_accession":[]},"is_claimable":false,"name":"Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation.","description":"<h4>Background</h4>Sarcopenia, the age-related decline in muscle mass and function, poses a major health risk to the elderly population. Although dietary advanced glycation end-products (AGEs) have been implicated in worsening sarcopenia, the precise molecular mechanisms remain unclear.<h4>Methods</h4>A sarcopenia animal model was established by feeding a high AGE diet to C57BL/6 mice. Muscle function and mass were assessed using grip strength tests, and rotarod tests. Proteomic analysis was used to identify differentially expressed proteins. Immunoprecipitation, mass spectrometry, and co-immunoprecipitation were employed to investigate protein interactions both in vivo and in vitro. Quantitative reverse transcription PCR and Western blotting were conducted to measure gene and protein expr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-13T03:05:11.231Z","creation":"2025-07-13T03:05:11.231Z"},"accession":"S-EPMC11977089","cross_references":{"pubmed":["40192801"],"doi":["10.1007/s00018-025-05657-1"]}}