{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dashti NK"],"funding":["NCI NIH HHS"],"pagination":["e70015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11977784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(11)"],"pubmed_abstract":["Conventional high-grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of osteosarcomas remain challenging due to unusual histology, such as sclerosing or osteoblastoma-like features, which may require molecular confirmation of their complex genetic alterations. We have encountered such a case in a 17-year-old man, who presented with a third metatarsal sclerotic bone lesion, found incidentally in the work-up of a foot trauma. The initial imaging revealed a lesion with sclerotic/blastic features proximally and lucent/lytic portion distally, findings interpreted consistent with osteoblastoma. The lesion was managed intra-lesionally with curettings and cryoablation; however, the microscopic findings were "],"journal":["Genes, chromosomes & cancer"],"pubmed_title":["Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion."],"pmcid":["PMC11977784"],"funding_grant_id":["P30 CA008748","P50 CA217694"],"pubmed_authors":["Dashti NK","Matcuk G","Agaimy A","Antonescu CR","Saoud C"],"additional_accession":[]},"is_claimable":false,"name":"Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion.","description":"Conventional high-grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of osteosarcomas remain challenging due to unusual histology, such as sclerosing or osteoblastoma-like features, which may require molecular confirmation of their complex genetic alterations. We have encountered such a case in a 17-year-old man, who presented with a third metatarsal sclerotic bone lesion, found incidentally in the work-up of a foot trauma. The initial imaging revealed a lesion with sclerotic/blastic features proximally and lucent/lytic portion distally, findings interpreted consistent with osteoblastoma. The lesion was managed intra-lesionally with curettings and cryoablation; however, the microscopic findings were ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-05-15T03:17:23.801Z","creation":"2026-05-15T03:12:17.337Z"},"accession":"S-EPMC11977784","cross_references":{"pubmed":["39604143"],"doi":["10.1002/gcc.70015"]}}