{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang W"],"funding":["Nanjing Medical Science and Technique Development Foundation"],"pagination":["164"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11977909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Unexplained recurrent spontaneous abortion (URSA) is a major problem in the field of human reproductive health. At present, several circRNAs have been reported to be differentially expressed and play an important biological function in pregnancy-related diseases. However, the role of circRNAs in URSA remains unclear.<h4>Methods</h4>Levels of circRNA and miRNA were examined by RT-qPCR. The si-RNA and overexpression plasmid were respectively used to silence and overexpress circRNA-ZFAND6. We investigated the biological function of circRNA-ZFAND6 on trophoblasts through CCK8, EdU, Flow cytometric assay, Wound-healing assays and Transwell. Dual luciferase activity assay was conducted to identify the interaction between miR-575 and circRNA-ZFAND6.<h4>Results</h4>We confirmed "],"journal":["BMC women's health"],"pubmed_title":["Silencing circRNA-ZFAND6 induces trophoblast apoptosis by activating the mitochondrial pathway through the miR-575/SOD2 axis in unexplained recurrent spontaneous abortion."],"pmcid":["PMC11977909"],"funding_grant_id":["ZKX21049"],"pubmed_authors":["Lv J","Li S","Jin S","Cheng Q","Wang W","Huang L","Miao Z"],"additional_accession":[]},"is_claimable":false,"name":"Silencing circRNA-ZFAND6 induces trophoblast apoptosis by activating the mitochondrial pathway through the miR-575/SOD2 axis in unexplained recurrent spontaneous abortion.","description":"<h4>Background</h4>Unexplained recurrent spontaneous abortion (URSA) is a major problem in the field of human reproductive health. At present, several circRNAs have been reported to be differentially expressed and play an important biological function in pregnancy-related diseases. However, the role of circRNAs in URSA remains unclear.<h4>Methods</h4>Levels of circRNA and miRNA were examined by RT-qPCR. The si-RNA and overexpression plasmid were respectively used to silence and overexpress circRNA-ZFAND6. We investigated the biological function of circRNA-ZFAND6 on trophoblasts through CCK8, EdU, Flow cytometric assay, Wound-healing assays and Transwell. Dual luciferase activity assay was conducted to identify the interaction between miR-575 and circRNA-ZFAND6.<h4>Results</h4>We confirmed ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-05T03:04:29.819Z","creation":"2025-07-05T03:04:29.819Z"},"accession":"S-EPMC11977909","cross_references":{"pubmed":["40200350"],"doi":["10.1186/s12905-025-03682-7"]}}